Chemical Property of AdipoRon
Chemical Property:
- Boiling Point:645.3±55.0 °C(Predicted)
- PKA:13.92±0.20(Predicted)
- PSA：58.64000
- Density:1.21±0.1 g/cm3(Predicted)
- LogP:4.40600
- Storage Temp.:room temp
- Solubility.:DMSO: soluble10mg/mL, clear
- XLogP3:4.7
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:8
- Exact Mass:428.20999276
- Heavy Atom Count:32
- Complexity:582
- Purity/Quality:
-
99%, *data from raw suppliers
AdipoRon *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xn,N
- Statements:
22-50/53
- Safety Statements:
60-61
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1CN(CCC1NC(=O)COC2=CC=C(C=C2)C(=O)C3=CC=CC=C3)CC4=CC=CC=C4
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Description
Adiponectin expressed by adipocytes exerts antidiabetic effects by binding to adiponectin receptor (AdipoR)1, which activates AMPK pathways, and AdipoR2, which activates PPARα pathways. AdipoRon is an orally active small molecule AdipoR agonist that binds AdipoR1 and AdipoR2 with KD values of 1.8 and 3.1 μM, respectively. At 50 mg/kg, it acts similarly to adiponectin, activating AMPK and PPARα pathways and reducing insulin resistance and glucose intolerance in wild type mice fed a high-fat diet and in genetically obese db/db mice.
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Uses
AdipoRon is an AdipoR agonist and activates AMPK and PPAR-α pathways in the muscle and liver. AdipoRon ameliorated diabetes of genetically obese rodent model db/db mice, and prolonged the shortened lifespan of db/db mice on a high-fat diet. AdipoRon is a promising therapeutic approach for the treatment of obesity-related diseases such as type 2 diabetes.
