Lenvatinib Impurity f

Base Information

Chemical Name:Lenvatinib Impurity f
CAS No.:417717-21-6
Molecular Formula:C21H18ClN3O5
Molecular Weight:427.844
Hs Code.:
Mol file:417717-21-6.mol

Synonyms:Lenvatinib Impurity f

Suppliers and Price of Lenvatinib Impurity f

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
DesaminoHydroxyLenvatinib
10mg
$ 420.00

Total 12 raw suppliers

Chemical Property of Lenvatinib Impurity f

Chemical Property:

Boiling Point:599.5±50.0 °C(Predicted)
PKA:2.74±0.30(Predicted)
PSA：109.78000
Density:1.50±0.1 g/cm3(Predicted)
LogP:5.13510

Purity/Quality:

97% ^*data from raw suppliers

DesaminoHydroxyLenvatinib ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Desamino Hydroxy Lenvatinib serves as a reagent for the synthesis of urea derivatives containing nitrogenous aromatic ring compounds that functions as angiogenesis inhibitors for treatment of diseases. It is also a derivative compound of Lenvatinib (L329400) that serves as orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors.

Technology Process of Lenvatinib Impurity f

There total 3 articles about Lenvatinib Impurity f which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 417717-20-5
methyl 4-[3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy]-7-methoxyquinoline-6-carboxylate

: 417717-21-6
4-[3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy]-7-methoxyquinoline-6-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; at 70 ℃; for 2.5h;
DOI:10.1016/j.ejmech.2019.02.065

Reference yield:

: 205448-66-4
methyl 4-chloro-7-methoxyquinoline-6-carboxylate

: 417717-21-6
4-[3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy]-7-methoxyquinoline-6-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 75 °C

2: sodium hydroxide / methanol; tetrahydrofuran / 2.5 h / 70 °C

With potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2019.02.065

Reference yield:

: 205448-65-3
7-methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylic acid methyl ester

: 417717-21-6
4-[3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy]-7-methoxyquinoline-6-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 125 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 30 h / 75 °C / Inert atmosphere

3.1: sodium hydroxide; water / methanol / 24 h / 40 °C

With thionyl chloride; water; potassium carbonate; sodium hydroxide; In methanol; N,N-dimethyl-formamide;