t-butyl 3-{5-chloro-4-[1-(phenylsulfonyl)-1H-indol-3-yl]-pyrimidin-2-ylamino}phenylcarbamate

Base Information

Chemical Name:t-butyl 3-{5-chloro-4-[1-(phenylsulfonyl)-1H-indol-3-yl]-pyrimidin-2-ylamino}phenylcarbamate
CAS No.:1453198-98-5
Molecular Formula:C₂₉H₂₆ClN₅O₄S
Molecular Weight:0
Hs Code.:

Synonyms:t-butyl 3-{5-chloro-4-[1-(phenylsulfonyl)-1H-indol-3-yl]-pyrimidin-2-ylamino}phenylcarbamate

Suppliers and Price of t-butyl 3-{5-chloro-4-[1-(phenylsulfonyl)-1H-indol-3-yl]-pyrimidin-2-ylamino}phenylcarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of t-butyl 3-{5-chloro-4-[1-(phenylsulfonyl)-1H-indol-3-yl]-pyrimidin-2-ylamino}phenylcarbamate

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

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Technology Process of t-butyl 3-{5-chloro-4-[1-(phenylsulfonyl)-1H-indol-3-yl]-pyrimidin-2-ylamino}phenylcarbamate

There total 2 articles about t-butyl 3-{5-chloro-4-[1-(phenylsulfonyl)-1H-indol-3-yl]-pyrimidin-2-ylamino}phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 882562-40-5
3-(2,5-dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole

: 68621-88-5
(3-aminophenyl)carbamic acid tert-butyl ester

: 1453198-98-5
t-butyl 3-{5-chloro-4-[1-(phenylsulfonyl)-1H-indol-3-yl]-pyrimidin-2-ylamino}phenylcarbamate

Guidance literature:: With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 80 ℃;
DOI:10.1021/jm400822z

Reference yield:

: 870717-93-4
1-(phenylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole

: 1453198-98-5
t-butyl 3-{5-chloro-4-[1-(phenylsulfonyl)-1H-indol-3-yl]-pyrimidin-2-ylamino}phenylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; acetonitrile / Inert atmosphere; Reflux

2: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; water; acetonitrile;
DOI:10.1021/jm400822z