7-Methoxy-2-oxo-1,2,3,4-tetrahydroquinoline-4-carbonitrile

Base Information

• Chemical Name: 7-Methoxy-2-oxo-1,2,3,4-tetrahydroquinoline-4-carbonitrile
• CAS No.: 1567360-56-8
• Molecular Formula: C11H10N2O2
• Molecular Weight: 202.2093
• Mol file: 1567360-56-8.mol

Synonyms:7-Methoxy-2-oxo-1,2,3,4-tetrahydroquinoline-4-carbonitrile

Chemical Property of 7-Methoxy-2-oxo-1,2,3,4-tetrahydroquinoline-4-carbonitrile

Chemical Property:

• Boiling Point: 435.9±45.0 °C(Predicted)
• PKA: 12.58±0.40(Predicted)
• Density: 1.27±0.1 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

7-Methoxy-2-oxo-1,2,3,4-tetrahydroquinoline-4-carbonitrile 95+% ^*data from reagent suppliers

Safty Information:

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Technology Process of 7-Methoxy-2-oxo-1,2,3,4-tetrahydroquinoline-4-carbonitrile

There total 5 articles about 7-Methoxy-2-oxo-1,2,3,4-tetrahydroquinoline-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-cyano-3-(4-methoxy-2-nitrophenyl)propanoate (1567360-55-7) → 7-methoxy-2-oxo-1,2,3,4-tetrahydroquinoline-4-carbonitrile (1567360-56-8)

Guidance literature:

With hydrogenchloride; tin; In methanol; water; at 20 ℃; for 2h;

Reference yield:

ethyl 3-cyano-3-(4-methoxy-2-nitrophenyl)propanoate (1567360-55-7) + sodium hydrogencarbonate (144-55-8) → 7-methoxy-2-oxo-1,2,3,4-tetrahydroquinoline-4-carbonitrile (1567360-56-8)

Guidance literature:

With hydrogenchloride; In methanol; ethyl acetate;

Reference yield:

(4-methoxy-2-nitro-phenyl)-acetonitrile (105003-90-5) → 7-methoxy-2-oxo-1,2,3,4-tetrahydroquinoline-4-carbonitrile (1567360-56-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / water; N,N-dimethyl-formamide

2: hydrogenchloride / methanol; ethyl acetate

With hydrogenchloride; potassium carbonate; In methanol; water; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

(4-methoxy-2-nitro-phenyl)-acetonitrile

ethyl 3-cyano-3-(4-methoxy-2-nitrophenyl)propanoate

sodium hydrogencarbonate

4-Methyl-3-nitroanisole

Downstream raw materials:

tert-butyl ((7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2-oxo-1,2,3,4-tetrahydroquinolin-4-yl)methyl)carbamate

4-(aminomethyl)-7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one

4-(((7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2-oxo-1,2,3,4-tetrahydroquinolin-4-yl)methyl)amino)-4-oxobutanoic acid

N-((7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2-oxo-1,2,3,4-tetrahydroquinolin-4-yl)methyl)-2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetamide

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