"5-(2-amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide "

Base Information

Chemical Name:"5-(2-amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide "
CAS No.:1384097-27-1
Molecular Formula:C₂₇H₁₈F₅N₅O₄S
Molecular Weight:603.529
Hs Code.:
Mol file:1384097-27-1.mol

Synonyms:"5-(2-amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide "

Suppliers and Price of "5-(2-amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide "

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 6 raw suppliers

Chemical Property of "5-(2-amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide "

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of "5-(2-amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide "

There total 10 articles about "5-(2-amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide " which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1383992-02-6
2-amino-6-iodo-3-(2-(trifluoromethyl)phenyl)quinazolin-4(3H)-one

: 1383992-65-1
N-(2,4-difluorophenyl)-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-sulfonamide

: 1384097-27-1,1384097-28-2
5-(2-amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2.4 - difluorophenyl)-2-methoxypyridin-3-sulfonamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,4-dioxane; water; at 80 ℃; for 1h;
DOI:10.1021/jm400781h

Reference yield: 21.0%

: 1383995-26-3
[5-{[(2,4-difluorophenyl)amino]sulfonyl}-6-(methyloxy)-3-pyridinyl]boronic acid

: 1383992-02-6
2-amino-6-iodo-3-(2-(trifluoromethyl)phenyl)quinazolin-4(3H)-one

: 1384097-27-1,1384097-28-2
5-(2-amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2.4 - difluorophenyl)-2-methoxypyridin-3-sulfonamide

Guidance literature:: With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 80 ℃; for 4h;

Reference yield:

: 1743-86-8
2-(trifluoromethyl)phenyl isothiocyanate

: 1384097-27-1,1384097-28-2
5-(2-amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2.4 - difluorophenyl)-2-methoxypyridin-3-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / 1,4-dioxane / 6 h / Reflux

2: trichlorophosphate; phosphorus pentachloride / Reflux

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 80 °C

4: trifluoroacetic acid / 0.33 h / 140 °C / Reflux; Microwave irradiation

5: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1 h / 80 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; phosphorus pentachloride; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm400781h