1-(3-BROMOBENZYL)-4-METHYLPIPERAZINE

Base Information

• Chemical Name: 1-(3-BROMOBENZYL)-4-METHYLPIPERAZINE
• CAS No.: 331977-03-8
• Molecular Formula: C12H17BrN2
• Molecular Weight: 269.184
• Hs Code.: 2933599090
• Mol file: 331977-03-8.mol

Synonyms:1-[(3-BROMOPHENYL)METHYL]-4-METHYLPIPERAZINE;1-(3-BROMOBENZYL)-4-METHYLPIPERAZINE;Piperazine, 1-[(3-bromophenyl)methyl]-4-methyl-

Chemical Property of 1-(3-BROMOBENZYL)-4-METHYLPIPERAZINE

Chemical Property:

• PSA: 6.48000
• LogP: 2.07230

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

1-(3-Bromobenzyl)-4-methylpiperazine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-BROMOBENZYL)-4-METHYLPIPERAZINE

There total 2 articles about 1-(3-BROMOBENZYL)-4-METHYLPIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-methyl-piperazine (109-01-3) + meta-bromobenzyl bromide (823-78-9) → 1-(3-bromobenzyl)-4-methylpiperazine (331977-03-8)

Guidance literature:

With triethylamine; In acetonitrile; at 20 ℃; for 3h;

DOI:10.1016/j.ejmech.2019.06.049

Reference yield: 66.0%

1-methyl-piperazine (109-01-3) + m-bromobenzoic aldehyde (3132-99-8) → 1-(3-bromobenzyl)-4-methylpiperazine (331977-03-8)

Guidance literature:

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;

DOI:10.1021/jm2011172

Reference yield: 78.0%

1-(3-bromobenzyl)-4-methylpiperazine (331977-03-8) + bis(pinacol)diborane (73183-34-3) → 1-methyl-4-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazine (883738-27-0)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 90 ℃; for 16h;

DOI:10.1016/j.ejmech.2019.06.049

upstream raw materials:

1-methyl-piperazine

meta-bromobenzyl bromide

m-bromobenzoic aldehyde

Downstream raw materials:

1-methyl-4-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazine

4-[(4-methyl-1H-indol-5-yl)amino]-5-[(E)-2-{3-[(4-methylpiperazin-1-yl)methyl]phenyl}vinyl]nicotinonitrile

9-chloro-2-(3-((4-methylpiperazin-1-yl)methyl)phenylamino)-5H-benzo[b]pyrimido[4,5-d]azepin-6(7H)-one

[8-(4-methanesulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-[3-(4-methylpiperazin-1-ylmethyl)phenyl]amine