3-(4-Methyl-1-piperazinylmethyl)benzeneboronic acid pinacol ester, 97%

Base Information

• Chemical Name: 3-(4-Methyl-1-piperazinylmethyl)benzeneboronic acid pinacol ester, 97%
• CAS No.: 883738-27-0
• Molecular Formula: C18H29 B N2 O2
• Molecular Weight: 316.251
• Hs Code.: 2933599090
• Mol file: 883738-27-0.mol

Synonyms:3-(4-Methyl-1-piperazinylmethyl)benzeneboronic acid pinacol ester, 97%

Chemical Property of 3-(4-Methyl-1-piperazinylmethyl)benzeneboronic acid pinacol ester, 97%

Chemical Property:

• Melting Point: 46 °C
• PSA: 24.94000
• LogP: 1.60900
• Storage Temp.: 2-8°C
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

3-((4-Methylpiperazin-1-yl)methyl)phenylboronicAcidPinacolEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-Methyl-1-piperazinylmethyl)benzeneboronic acid pinacol ester, 97%

There total 5 articles about 3-(4-Methyl-1-piperazinylmethyl)benzeneboronic acid pinacol ester, 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-methyl-piperazine (109-01-3) + (3‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)phenyl)methanol (443776-76-9) → 1-methyl-4-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazine (883738-27-0)

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; sodium carbonate; bis[2-(diphenylphosphino)phenyl] ether; In 5,5-dimethyl-1,3-cyclohexadiene; at 155 ℃; for 24h; Inert atmosphere; Reflux;

DOI:10.1021/ol402271a

Reference yield: 78.0%

1-(3-bromobenzyl)-4-methylpiperazine (331977-03-8) + bis(pinacol)diborane (73183-34-3) → 1-methyl-4-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazine (883738-27-0)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 90 ℃; for 16h;

DOI:10.1016/j.ejmech.2019.06.049

Reference yield:

1-methyl-piperazine (109-01-3) + 2-(3-(bromomethyl)phenyl)-4,4,5,5,-tetramethyl-1,3,2-dioxaborolane (214360-74-4) → 1-methyl-4-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazine (883738-27-0)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 2h;

upstream raw materials:

1-methyl-piperazine

2-(3-(bromomethyl)phenyl)-4,4,5,5,-tetramethyl-1,3,2-dioxaborolane

1-(3-bromobenzyl)-4-methylpiperazine

bis(pinacol)diborane

Downstream raw materials:

(R)-3-(4-(5-(3-((4-methylpiperazin-1-yl)methyl)phenyl)thiophen-2-yl)-1H-1,2,3-triazol-1-yl)quinuclidine

Refernces

• 1、 Ma, Winson M. J.,James, Tony D.,Williams, Jonathan M. J.. "Synthesis of amines with pendant boronic esters by borrowing hydrogen catalysis". supporting information. p. 4850 - 4853. Retrieved 2013/10/08.
• 2、 -. "KINASE INHIBITORS". Page/Page column 108-109. . Retrieved 2010/10/20.