tert-butyl(2-(3-(5-amino-1-methyl-1H-pyrazol-4-yl)ureido)ethyl)carbamate

Base Information

• Chemical Name: tert-butyl(2-(3-(5-amino-1-methyl-1H-pyrazol-4-yl)ureido)ethyl)carbamate
• CAS No.: 689293-67-2
• Molecular Formula: C12H22N6O3
• Molecular Weight: 298.34
• Mol file: 689293-67-2.mol

Synonyms:tert-butyl(2-(3-(5-amino-1-methyl-1H-pyrazol-4-yl)ureido)ethyl)carbamate

Chemical Property of tert-butyl(2-(3-(5-amino-1-methyl-1H-pyrazol-4-yl)ureido)ethyl)carbamate

Chemical Property:

• PSA: 123.30000
• LogP: 2.08450

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

tert-Butyl(2-(3-(5-amino-1-methyl-1H-pyrazol-4-yl)ureido)ethyl)carbamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl(2-(3-(5-amino-1-methyl-1H-pyrazol-4-yl)ureido)ethyl)carbamate

There total 2 articles about tert-butyl(2-(3-(5-amino-1-methyl-1H-pyrazol-4-yl)ureido)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

tert-butyl (2-(3-((5-(tert-butoxycarbonyl)amino)-1-methyl-1H-pyrazol-4-yl)ureido)ethyl)carbamate → tert-butyl (2-(3-(5-amino-1-methyl-1H-pyrazol-4-yl)ureido)ethyl)carbamate (689293-67-2)

Guidance literature:

With ethanol; In water; at 85 - 110 ℃; for 6.5h;

Reference yield:

4,5-diamino-1-methylpyrazole sulfate (20055-01-0) + N-BOC-1,2-diaminoethane (57260-73-8) + 1,1'-carbonyldiimidazole (530-62-1) → tert-butyl (2-(3-(5-amino-1-methyl-1H-pyrazol-4-yl)ureido)ethyl)carbamate (689293-67-2)

Guidance literature:

N-BOC-1,2-diaminoethane; 1,1'-carbonyldiimidazole; In chloroform; at 0 - 20 ℃; for 1h;

4,5-diamino-1-methylpyrazole sulfate; With N-ethylbis(isobutyl)amine; In chloroform; at 50 ℃; for 15h;

Reference yield:

tert-butyl (2-(3-(5-amino-1-methyl-1H-pyrazol-4-yl)ureido)ethyl)carbamate (689293-67-2) + trityl chloride (76-83-5) → 4-(3-{2-[(tert-butoxycarbonyl)amino]ethyl}ureido)-1-methyl-5-triphenylmethylaminopyrazole (689293-69-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 19h;

upstream raw materials:

4,5-diamino-1-methylpyrazole sulfate

N-BOC-1,2-diaminoethane

1,1'-carbonyldiimidazole

Downstream raw materials:

4-(3-{2-[(tert-butoxycarbonyl)amino]ethyl}ureido)-1-methyl-5-triphenylmethylaminopyrazole

7β-[(Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(1-carboxy-1-methylethoxyimino) acetamido]-3-{3-amino-4-[3-(2-aminoethyl) ureido]-2-methyl-1-pyrazolio} methyl-3-cephem-4-carboxylate