N-[2-[[[[1-Methyl-5-[(triphenylmethyl)amino]-1H-pyrazol-4-yl]amino]carbonyl]amino]ethyl]carbamic acid tert-butyl ester

Base Information

• Chemical Name: N-[2-[[[[1-Methyl-5-[(triphenylmethyl)amino]-1H-pyrazol-4-yl]amino]carbonyl]amino]ethyl]carbamic acid tert-butyl ester
• CAS No.: 689293-69-4
• Molecular Formula: C₃₁H₃₆N₆O₃
• Molecular Weight: 540.665
• Mol file: 689293-69-4.mol

Synonyms:

Chemical Property of N-[2-[[[[1-Methyl-5-[(triphenylmethyl)amino]-1H-pyrazol-4-yl]amino]carbonyl]amino]ethyl]carbamic acid tert-butyl ester

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 680.4±55.0 °C(Predicted)
• PKA: 12.29±0.46(Predicted)
• Density: 1.17
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99.9% ^*data from raw suppliers

2-METHYL-3-TRITYLAMINO-4-[(2-N-BOCAMINO)ETHYLAMINOACARBONYL]AMINO-2H-PYRAZOLE 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-[[[[1-Methyl-5-[(triphenylmethyl)amino]-1H-pyrazol-4-yl]amino]carbonyl]amino]ethyl]carbamic acid tert-butyl ester

There total 10 articles about N-[2-[[[[1-Methyl-5-[(triphenylmethyl)amino]-1H-pyrazol-4-yl]amino]carbonyl]amino]ethyl]carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-methyl-4-phenoxycarbonylamino-5-triphenylmethylaminopyrazole (689294-26-6) + N-BOC-1,2-diaminoethane (57260-73-8) → 4-(3-{2-[(tert-butoxycarbonyl)amino]ethyl}ureido)-1-methyl-5-triphenylmethylaminopyrazole (689293-69-4)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2008.07.085

Reference yield: 62.0%

N-BOC-1,2-diaminoethane (57260-73-8) + 1-methyl-5-(tritylamino)-1H-pyrazole-4-carboxamide → 4-(3-{2-[(tert-butoxycarbonyl)amino]ethyl}ureido)-1-methyl-5-triphenylmethylaminopyrazole (689293-69-4)

Guidance literature:

With [bis(acetoxy)iodo]benzene; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 ℃; for 1.25h;

Reference yield:

tert-butyl (2-(3-(5-amino-1-methyl-1H-pyrazol-4-yl)ureido)ethyl)carbamate (689293-67-2) + trityl chloride (76-83-5) → 4-(3-{2-[(tert-butoxycarbonyl)amino]ethyl}ureido)-1-methyl-5-triphenylmethylaminopyrazole (689293-69-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 19h;

upstream raw materials:

tert-butyl (2-(3-(5-amino-1-methyl-1H-pyrazol-4-yl)ureido)ethyl)carbamate

trityl chloride

1-methyl-4-phenoxycarbonylamino-5-triphenylmethylaminopyrazole

N-BOC-1,2-diaminoethane