3-Hydroxymonoethylglycinexylidide

Base Information

• Chemical Name: 3-Hydroxymonoethylglycinexylidide
• CAS No.: 34604-56-3
• Molecular Formula: C₁₂H₁₈N₂O₂
• Molecular Weight: 222.287
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID80188178
• Nikkaji Number: J356.054F
• Wikidata: Q27149619
• Mol file: 34604-56-3.mol

Synonyms:3-hydroxy-monoethylglycinexylidide;3-OH-MEGX;N-(3-hydroxy-2,6-dimethylphenyl)-2-ethylaminoacetamide

Chemical Property of 3-Hydroxymonoethylglycinexylidide

Chemical Property:

• Vapor Pressure: 2.51E-06mmHg at 25°C
• Boiling Point: 380.3°C at 760 mmHg
• PKA: 10.24±0.23(Predicted)
• Flash Point: 183.8°C
• PSA: 64.85000
• Density: 1.137g/cm³
• LogP: 2.59740
• Storage Temp.: Refrigerator
• Solubility.: Acetonitrile (Slightly), Methanol (Slightly)
• XLogP3: 1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 222.136827821
• Heavy Atom Count: 16
• Complexity: 233

Purity/Quality:

99.90% ^*data from raw suppliers

3-Hydroxy-N-desethylLidocaine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCNCC(=O)NC1=C(C=CC(=C1C)O)C

Technology Process of 3-Hydroxymonoethylglycinexylidide

There total 4 articles about 3-Hydroxymonoethylglycinexylidide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Hydroxylidocaine (34604-55-2) → 3-Hydroxy-monoethylglycinexylidide (34604-56-3)

Guidance literature:

With glucose-6-phosphate dehydrogenase; Tris-HCl buffer; D-glucose 6-phosphate; hepatic microsomal suspension; NADP; In water; at 37 ℃; Rate constant; Michaelis constant;

DOI:10.1002/jps.2600730140

Reference yield:

N-(2,6-dimethylphenyl)-2-ethylaminoacetamide (7728-40-7) → Glycine xylidide (18865-38-8) + 3-Hydroxy-monoethylglycinexylidide (34604-56-3)

Guidance literature:

at 37 ℃; in vitro methabolism; V_max (maximal velocity of metabolism) and K_m (Michaelis constant) for ring hydroxylation and N-deethylation in microsomal incubation mixture (pH 7.4);

DOI:10.1002/jps.2600741116

Reference yield:

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide (137-58-6) → 3-Hydroxylidocaine (34604-55-2) + Glycine xylidide (18865-38-8) + N-(2,6-dimethylphenyl)-2-ethylaminoacetamide (7728-40-7) + 3-Hydroxy-monoethylglycinexylidide (34604-56-3)

Guidance literature:

at 37 ℃; in vitro methabolism; V_max (maximal velocity of metabolism) and K_m (Michaelis constant) for ring hydroxylation and N-deethylation in microsomal incubation mixture (pH 7.4);

DOI:10.1002/jps.2600741116

upstream raw materials:

3-Hydroxylidocaine

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

N-(2,6-dimethylphenyl)-2-ethylaminoacetamide