3-Hydroxylidocaine

Base Information

• Chemical Name: 3-Hydroxylidocaine
• CAS No.: 34604-55-2
• Molecular Formula: C14H22 N2 O2
• Molecular Weight: 250.341
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID20188177
• Nikkaji Number: J356.053H
• Wikidata: Q26998316
• Mol file: 34604-55-2.mol

Synonyms:3-hydroxylidocaine

Chemical Property of 3-Hydroxylidocaine

Chemical Property:

• Vapor Pressure: 1.15E-06mmHg at 25°C
• Melting Point: 192-195°C
• Boiling Point: 390.8°C at 760 mmHg
• PKA: 10.18±0.23(Predicted)
• Flash Point: 190.2°C
• PSA: 52.57000
• Density: 1.103g/cm³
• LogP: 2.36230
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 250.168127949
• Heavy Atom Count: 18
• Complexity: 267

Purity/Quality:

98%Min ^*data from raw suppliers

3-Hydroxy lidocaine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)CC(=O)NC1=C(C=CC(=C1C)O)C
• Description: 3’-hydroxy Lidocaine is an active metabolite of lidocaine formed by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4.
• Uses: A metabolite of Lidocaine (L397800).

Technology Process of 3-Hydroxylidocaine

There total 6 articles about 3-Hydroxylidocaine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-diethylamine-N-(3-formyl-2,6-dimethyl-phenyl)-acetamide (1044658-04-9) → 3-Hydroxylidocaine (34604-55-2)

Guidance literature:

2-diethylamine-N-(3-formyl-2,6-dimethyl-phenyl)-acetamide; With selenium(IV) oxide; dihydrogen peroxide; In dichloromethane; water; at 20 ℃; for 24h;

With lithium hydroxide; In 1,4-dioxane;

Reference yield:

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide (137-58-6) → 4-hydroxylidocaine (39942-41-1) + 3-Hydroxylidocaine (34604-55-2)

Guidance literature:

With water; trifluoroacetic acid; In acetonitrile; for 0.5h; pH=5; Reagent/catalyst; Electrochemical reaction; Inert atmosphere;

DOI:10.1016/j.electacta.2016.12.089

Reference yield:

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide (137-58-6) → lidocaine N-oxide (2903-45-9) + 4-hydroxylidocaine (39942-41-1) + 3-Hydroxylidocaine (34604-55-2) + N-(2,6-dimethylphenyl)-2-ethylaminoacetamide (7728-40-7) + 2-diethylamino-2'-hydroxymethyl-6'-methyl acetanilide (64585-18-8)

Guidance literature:

With tetrabutylammonium perchlorate; In water; acetonitrile; at 20 ℃; for 0.5h; Electrochemical reaction;

DOI:10.1021/ac200897p

upstream raw materials:

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

2-diethylamine-N-(3-formyl-2,6-dimethyl-phenyl)-acetamide

N-(3-bromo-2,6-dimethyl-phenyl)-2-diethylamine-acetamide

Downstream raw materials:

3-Hydroxy-monoethylglycinexylidide

N-(3-benzyloxy-2,6-dimethyl-phenyl)-2-diethylamine-acetamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 34604-55-2 3-hydroxylidocaine

Send

Send

Metric Ton KG G Pound L ML

Send

Send