3-(Boc-aMino)-3-(4-chlorophenyl)-1-propanol

Base Information

• Chemical Name: 3-(Boc-aMino)-3-(4-chlorophenyl)-1-propanol
• CAS No.: 886493-66-9
• Molecular Formula: C14H20ClNO3
• Molecular Weight: 285.771
• Hs Code.: 2924299090
• Mol file: 886493-66-9.mol

Synonyms:3-(Boc-aMino)-3-(4-chlorophenyl)-1-propanol;[1-(4-chlorophenyl)-3-hydroxypropyl]Carbamic acid 1,1-dimethylethyl ester

Chemical Property of 3-(Boc-aMino)-3-(4-chlorophenyl)-1-propanol

Chemical Property:

• Boiling Point: 432.7±40.0 °C(Predicted)
• PKA: 11?+-.0.46(Predicted)
• PSA: 62.05000
• Density: 1.171±0.06 g/cm3(Predicted)
• LogP: 3.49260

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl(1-(4-chlorophenyl)-3-hydroxypropyl)carbamate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(Boc-aMino)-3-(4-chlorophenyl)-1-propanol

There total 2 articles about 3-(Boc-aMino)-3-(4-chlorophenyl)-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-amino-3-(4-chlorophenyl)propan-1-ol (68208-26-4,1213362-28-7,886061-26-3) → tert-butyl 1-(4-chlorophenyl)-3-hydroxypropylcarbamate (886493-66-9)

Guidance literature:

In dichloromethane; at 22 ℃; for 2h;

Reference yield:

3-amino-3-(4-chlorophenyl)propionic acid (19947-39-8,131690-61-4) → tert-butyl 1-(4-chlorophenyl)-3-hydroxypropylcarbamate (886493-66-9)

Guidance literature:

Multi-step reaction with 2 steps

1: borane-THF / tetrahydrofuran / 5.83 h / 0 - 22 °C / Inert atmosphere

2: dichloromethane / 2 h / 22 °C

With borane-THF; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm301762v

Reference yield: 88.0%

tert-butyl 1-(4-chlorophenyl)-3-hydroxypropylcarbamate (886493-66-9) + methanesulfonyl chloride (124-63-0) → 3-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propyl Methanesulfonate (1143534-27-3)

Guidance literature:

With triethylamine; In dichloromethane; at 22 ℃; for 2h;

upstream raw materials:

di-tert-butyl dicarbonate

3-amino-3-(4-chlorophenyl)propan-1-ol

3-amino-3-(4-chlorophenyl)propionic acid

Downstream raw materials:

tert-butyl 1-(4-chlorophenyl)-3-methoxypropylcarbamate

3-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propyl Methanesulfonate

tert-butyl 1-(4-chlorophenyl)-3-sulfamoylpropylcarbamate

3-amino-3-(4-chlorophenyl)propane-1-sulfonamide