3-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propyl Methanesulfonate

Base Information

• Chemical Name: 3-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propyl Methanesulfonate
• CAS No.: 1143534-27-3
• Molecular Formula: C₁₅H₂₂ClNO₅S
• Molecular Weight: 363.862
• Mol file: 1143534-27-3.mol

Synonyms:3-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propyl Methanesulfonate

Chemical Property of 3-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propyl Methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propyl Methanesulfonate

There total 3 articles about 3-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propyl Methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

tert-butyl 1-(4-chlorophenyl)-3-hydroxypropylcarbamate (886493-66-9) + methanesulfonyl chloride (124-63-0) → 3-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propyl Methanesulfonate (1143534-27-3)

Guidance literature:

With triethylamine; In dichloromethane; at 22 ℃; for 2h;

Reference yield:

3-amino-3-(4-chlorophenyl)propan-1-ol (68208-26-4,1213362-28-7,886061-26-3) → 3-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propyl Methanesulfonate (1143534-27-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 2 h / 22 °C

2: triethylamine / dichloromethane / 2 h / 22 °C

With triethylamine; In dichloromethane;

DOI:10.1021/jm301762v

Reference yield:

3-amino-3-(4-chlorophenyl)propionic acid (19947-39-8,131690-61-4) → 3-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propyl Methanesulfonate (1143534-27-3)

Guidance literature:

Multi-step reaction with 3 steps

1: borane-THF / tetrahydrofuran / 5.83 h / 0 - 22 °C / Inert atmosphere

2: dichloromethane / 2 h / 22 °C

3: triethylamine / dichloromethane / 2 h / 22 °C

With borane-THF; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm301762v

upstream raw materials:

tert-butyl 1-(4-chlorophenyl)-3-hydroxypropylcarbamate

methanesulfonyl chloride

3-amino-3-(4-chlorophenyl)propionic acid

3-amino-3-(4-chlorophenyl)propan-1-ol

Downstream raw materials:

tert-butyl 1-(4-chlorophenyl)-3-(dimethylamino)propylcarbamate

S-3-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propyl ethanethioate

tert-butyl 1-(4-chlorophenyl)-3-(methylamino)propylcarbamate

tert-butyl 1-(4-chlorophenyl)-3-sulfamoylpropylcarbamate