N-(4-aminophenyl)pyridine-2-carboxamide

Base Information

• Chemical Name: N-(4-aminophenyl)pyridine-2-carboxamide
• CAS No.: 491839-49-7
• Molecular Formula: C12H11N3O
• Molecular Weight: 213.239
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID00355744
• Wikidata: Q82134798
• Mol file: 491839-49-7.mol

Synonyms:491839-49-7;N-(4-aminophenyl)pyridine-2-carboxamide;N-(4-Aminophenyl)picolinamide;pyridine-2-carboxylic acid(4-amino-phenyl)-amide;Pyridine-2-carboxylic acid (4-amino-phenyl)-amide;BAS 02751830;Oprea1_518106;Oprea1_762782;SCHEMBL3099628;DTXSID00355744;RALBTYIQUXBZBK-UHFFFAOYSA-N;AKOS000126664;SR-01000361609;Pyridine-2-carboxylic acid, (4-amino-phenyl)-amide;SR-01000361609-1;BRD-K51143135-001-01-7;N-(4-Aminophenyl)-2-pyridinecarboxamide, AldrichCPR

Chemical Property of N-(4-aminophenyl)pyridine-2-carboxamide

Chemical Property:

• PSA: 68.01000
• LogP: 2.57030
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 213.090211983
• Heavy Atom Count: 16
• Complexity: 236

Purity/Quality:

98%min ^*data from raw suppliers

Pyridine-2-carboxylic acid(4-amino-phenyl)-amide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)C(=O)NC2=CC=C(C=C2)N

Technology Process of N-(4-aminophenyl)pyridine-2-carboxamide

There total 9 articles about N-(4-aminophenyl)pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl N-[4-(pyridine-2-amido)phenyl]carbamate → N-(4-aminophenyl)pyridine-2-carboxamide (491839-49-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h; pH=7;

Reference yield: 97.0%

→ N-(4-aminophenyl)pyridine-2-carboxamide (491839-49-7)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃; for 4h; under 750.075 Torr;

Reference yield: 41.64%

2-Picolinic acid (98-98-6) + 4-nitro-aniline (100-01-6,104810-17-5) → N-(4-aminophenyl)pyridine-2-carboxamide (491839-49-7)

Guidance literature:

2-Picolinic acid; With thionyl chloride; In dichloromethane; for 3h; Reflux;

4-nitro-aniline; In dichloromethane; Reflux;

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃;

upstream raw materials:

pyridine-2-carbonyl chloride

2-Picolinic acid

4-nitro-aniline

pyridine-2-carboxylic acid (4-nitro-phenyl)amide

Downstream raw materials:

N-(4-((3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino)phenyl)picolinamide