1-DIFLUOROMETHYL-5-METHYL-1H-PYRAZOLE

Base Information

• Chemical Name: 1-DIFLUOROMETHYL-5-METHYL-1H-PYRAZOLE
• CAS No.: 1004096-15-4
• Molecular Formula: C₅H₆F₂N₂
• Molecular Weight: 132.113
• Hs Code.: 2933199090
• Mol file: 1004096-15-4.mol

Synonyms:TIMTEC-BB SBB000018;1-DIFLUOROMETHYL-5-METHYL-1H-PYRAZOLE;AKOS B017760;ART-CHEM-BB B017760

Chemical Property of 1-DIFLUOROMETHYL-5-METHYL-1H-PYRAZOLE

Chemical Property:

• PSA: 17.82000
• LogP: 1.58660

Purity/Quality:

97% ^*data from raw suppliers

1-(Difluoromethyl)-4-iodo-5-methyl-1H-pyrazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-DIFLUOROMETHYL-5-METHYL-1H-PYRAZOLE

There total 2 articles about 1-DIFLUOROMETHYL-5-METHYL-1H-PYRAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Chlorodifluoromethane (75-45-6) + 3(5)-methylpyrazole (88054-14-2) → 1-(difluoromethyl)-5-methyl-1H-pyrazole (1004096-15-4) + 1-(difluoromethyl)-3-methyl-1H-pyrazole

Guidance literature:

With 18-crown-6 ether; potassium hydroxide; In tetrahydrofuran; water; at 40 - 45 ℃; Reagent/catalyst; Solvent; Overall yield = 60 %;

DOI:10.1007/s10593-019-02465-x

Reference yield:

sodium chlorodifluoroacetate (1895-39-2) + 3(5)-methylpyrazole (88054-14-2) → 1-(difluoromethyl)-5-methyl-1H-pyrazole (1004096-15-4) + 1-(difluoromethyl)-3-methyl-1H-pyrazole

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 110 - 140 ℃; for 0.05 - 0.0666667h;

DOI:10.1007/s10593-019-02465-x

upstream raw materials:

Chlorodifluoromethane

3⁽⁵⁾-methylpyrazole

sodium chlorodifluoroacetate