5-BROMO-3-(1,4-DIOXASPIRO[4.5]DEC-7-EN-8-YL)-1H-INDOLE

Base Information

• Chemical Name: 5-BROMO-3-(1,4-DIOXASPIRO[4.5]DEC-7-EN-8-YL)-1H-INDOLE
• CAS No.: 282546-99-0
• Molecular Formula: C16H16BrNO2
• Molecular Weight: 334.213
• Hs Code.: 2934999090
• Mol file: 282546-99-0.mol

Synonyms:5-BROMO-3-(1,4-DIOXASPIRO[4.5]DEC-7-EN-8-YL)-1H-INDOLE;8-(5-Bromo-1H-indol-3-yl)-1,4-dioxaspiro[4.5]dec-7-ene, 4-(5-Bromo-1H-indol-3-yl)cyclohex-3-en-1-one ethylene ketal

Chemical Property of 5-BROMO-3-(1,4-DIOXASPIRO[4.5]DEC-7-EN-8-YL)-1H-INDOLE

Chemical Property:

• Melting Point: 179-181
• Boiling Point: 503.0±50.0 °C(Predicted)
• PKA: 16.12±0.30(Predicted)
• PSA: 34.25000
• Density: 1.54±0.1 g/cm3(Predicted)
• LogP: 4.24080

Purity/Quality:

98%min ^*data from raw suppliers

5-Bromo-3-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)-1H-indole ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-3-(1,4-DIOXASPIRO[4.5]DEC-7-EN-8-YL)-1H-INDOLE

There total 2 articles about 5-BROMO-3-(1,4-DIOXASPIRO[4.5]DEC-7-EN-8-YL)-1H-INDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

5-bromo-1H-indole (10075-50-0) + cyclohexanedione monoethylene ketal (4746-97-8) → 5-bromo-3-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1H-indole (282546-99-0)

Guidance literature:

With potassium hydroxide; In methanol; Reflux; Inert atmosphere;

Reference yield: 78.0%

→ 5-bromo-3-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1H-indole (282546-99-0)

Guidance literature:

Reference yield: 70.0%

5-bromo-3-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1H-indole (282546-99-0) + benzyl bromide (100-39-0) → 5-bromo-1-(cyclohexylmethyl)-3-(1,4-dioxaspiro[4.5]dec-en-8-yl)-1H-indole

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; Inert atmosphere;

upstream raw materials:

5-bromo-1H-indole

cyclohexanedione monoethylene ketal