benzyl 1-(tert-butoxycarbonyl)cyclopropylcarbamate

Base Information

Chemical Name:benzyl 1-(tert-butoxycarbonyl)cyclopropylcarbamate
CAS No.:1159735-75-7
Molecular Formula:C16H21NO4
Molecular Weight:291.347
Hs Code.:
Mol file:1159735-75-7.mol

Synonyms:benzyl 1-(tert-butoxycarbonyl)cyclopropylcarbamate

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Chemical Property of benzyl 1-(tert-butoxycarbonyl)cyclopropylcarbamate

Chemical Property:

PSA：64.63000
LogP:3.17800

Purity/Quality:

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Technology Process of benzyl 1-(tert-butoxycarbonyl)cyclopropylcarbamate

There total 5 articles about benzyl 1-(tert-butoxycarbonyl)cyclopropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1268842-79-0
1-(tert-butoxycarbonyl)cyclopropane-1-carboxylic acid

: 100-51-6,185532-71-2
benzyl alcohol

: 1159735-75-7
tert-butyl 1-(((benzyloxy)carbonyl)amino)cyclopropane-1-carboxylate

Guidance literature:: 1-(tert-butoxycarbonyl)cyclopropane-1-carboxylic acid; With diphenyl phosphoryl azide; triethylamine; In dichloromethane; for 2h; Inert atmosphere; Reflux;

benzyl alcohol; In dichloromethane; for 5h; Reflux;
DOI:10.1021/acsmedchemlett.7b00544

Reference yield: 41.0%

: 84677-06-5
(benzyloxycarbonylamino)cyclopropanecarboxylic acid

: 75-65-0
tert-butyl alcohol

: 1159735-75-7
tert-butyl 1-(((benzyloxy)carbonyl)amino)cyclopropane-1-carboxylate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 42726-73-8
methyl t-butyl malonate

: 1159735-75-7
tert-butyl 1-(((benzyloxy)carbonyl)amino)cyclopropane-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: sodium hydroxide / ethanol

3.1: triethylamine; diphenyl phosphoryl azide / dichloromethane / 2 h / Inert atmosphere; Reflux

3.2: 5 h / Reflux

With diphenyl phosphoryl azide; potassium carbonate; triethylamine; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.7b00544