9-AMino-3-Boc-3-azaspiro[5.5]undecane

Base Information

• Chemical Name: 9-AMino-3-Boc-3-azaspiro[5.5]undecane
• CAS No.: 1272758-41-4
• Molecular Formula: C15H28N2O2
• Molecular Weight: 268.39502
• Hs Code.: 2933990090
• Mol file: 1272758-41-4.mol

Synonyms:9-AMino-3-Boc-3-azaspiro[5.5]undecane;tert-butyl 9-amino-3-azaspiro[5.5]undecane-3-carboxylate

Chemical Property of 9-AMino-3-Boc-3-azaspiro[5.5]undecane

Chemical Property:

• PSA: 55.56000
• LogP: 3.54320
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

tert-butyl9-amino-3-azaspiro[5.5]undecane-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9-AMino-3-Boc-3-azaspiro[5.5]undecane

There total 8 articles about 9-AMino-3-Boc-3-azaspiro[5.5]undecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

tert-butyl 9-hydroxyimino-3-azaspiro[5.5]undecane-3-carboxylate → 9-amino-3-azaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester (1272758-41-4)

Guidance literature:

With ammonium hydroxide; hydrogen; In methanol; at 25 ℃; for 3h; under 2585.81 Torr;

Reference yield: 22.4%

9-oxo-3-azaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester (873924-08-4) → 9-amino-3-azaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester (1272758-41-4)

Guidance literature:

9-oxo-3-azaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester; With titanium(IV) isopropylate; ammonia; In methanol; ethanol; at 20 ℃;

With methanol; sodium tetrahydroborate; In ethanol; at 20 ℃; for 5h;

Reference yield:

9-benzylamino-3-azaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester → 9-amino-3-azaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester (1272758-41-4)

Guidance literature:

With hydrogen; palladium(II) hydroxide; In methanol; at 20 ℃; for 18h; Inert atmosphere;

upstream raw materials:

9-oxo-3-azaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester

9-oxo-3-azaspiro[5.5]undec-7-ene-3-carboxylic acid tert-butyl ester

tert butyl 4-formylpiperidine-1-carboxylate

tert-butyl 9-hydroxy-3-azaspiro[5.5 ]undecane-3-carboxylate

Refernces

• 1、 -. "PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE". . . Retrieved 2018/04/27.
• 2、 -. "Substituted heteroaryl compounds and composition thereof, and applicaitons of compounds and composition". Paragraph 0819; 0820; 0821; 0940; 0941; 0942. . Retrieved 2017/07/31.