3-Azaspiro[5.5]undec-7-ene-3-carboxylic acid, 9-oxo-, 1,1-diMethylethyl ester

Base Information

Chemical Name:3-Azaspiro[5.5]undec-7-ene-3-carboxylic acid, 9-oxo-, 1,1-diMethylethyl ester
CAS No.:873924-07-3
Molecular Formula:C15H23NO3
Molecular Weight:265.34800
Hs Code.:2933990090
Mol file:873924-07-3.mol

Synonyms:

Suppliers and Price of 3-Azaspiro[5.5]undec-7-ene-3-carboxylic acid, 9-oxo-, 1,1-diMethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
tert-Butyl 9-oxo-3-azaspiro[5.5]undec-7-ene-3-carboxylate 95%
1g
$ 922.00

Matrix Scientific
tert-Butyl 9-oxo-3-azaspiro[5.5]undec-7-ene-3-carboxylate 95%
250mg
$ 334.00

Crysdot
tert-Butyl9-oxo-3-azaspiro[5.5]undec-7-ene-3-carboxylate 95+%
250mg
$ 295.00

Crysdot
tert-Butyl9-oxo-3-azaspiro[5.5]undec-7-ene-3-carboxylate 95+%
1g
$ 596.00

Alichem
tert-Butyl9-oxo-3-azaspiro[5.5]undec-7-ene-3-carboxylate
1g
$ 653.12

Alichem
tert-Butyl9-oxo-3-azaspiro[5.5]undec-7-ene-3-carboxylate
250mg
$ 315.12

AK Scientific
Tert-Butyl9-Oxo-3-Azaspiro[5.5]Undec-7-Ene-3-Carboxylate
100mg
$ 158.00

Total 14 raw suppliers

Chemical Property of 3-Azaspiro[5.5]undec-7-ene-3-carboxylic acid, 9-oxo-, 1,1-diMethylethyl ester

Chemical Property:

PSA：46.61000
LogP:2.86070
Storage Temp.:2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 9-oxo-3-azaspiro[5.5]undec-7-ene-3-carboxylate 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Azaspiro[5.5]undec-7-ene-3-carboxylic acid, 9-oxo-, 1,1-diMethylethyl ester

There total 5 articles about 3-Azaspiro[5.5]undec-7-ene-3-carboxylic acid, 9-oxo-, 1,1-diMethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 78-94-4,25038-87-3
methyl vinyl ketone

: 137076-22-3
tert butyl 4-formylpiperidine-1-carboxylate

: 873924-07-3
9-oxo-3-azaspiro[5.5]undec-7-ene-3-carboxylic acid tert-butyl ester

Guidance literature:: tert butyl 4-formylpiperidine-1-carboxylate; With pyrrolidine; In cyclohexane; at 25 - 30 ℃; Reflux; Dean-Stark; Large scale;

methyl vinyl ketone; In cyclohexane; at 25 - 30 ℃; Large scale;

Reference yield:

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 873924-07-3
9-oxo-3-azaspiro[5.5]undec-7-ene-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.25 h / -70 °C / Inert atmosphere

1.2: 1 h / -70 °C

2.1: potassium hydroxide / tetrahydrofuran; ethanol / 16.08 h / -5 - 15 °C

With oxalyl dichloride; dimethyl sulfoxide; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 2971-79-1
isonipecotic acid methyl ester

: 873924-07-3
9-oxo-3-azaspiro[5.5]undec-7-ene-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 12 h / 25 °C

2: lithium borohydride / tetrahydrofuran / 0 °C / Reflux

3: pyridinium chlorochromate / dichloromethane / 0 - 25 °C

4: potassium hydroxide / tetrahydrofuran; ethanol / 0 - 25 °C

With lithium borohydride; triethylamine; pyridinium chlorochromate; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; 3: Swern Oxidation;