DL-NORLEUCINE METHYL ESTER

Base Information

• Chemical Name: DL-NORLEUCINE METHYL ESTER
• CAS No.: 51220-79-2
• Molecular Formula: C7H15NO2
• Molecular Weight: 145.202
• Hs Code.: 2922499990
• Mol file: 51220-79-2.mol

Synonyms:DL-NORLEUCINE METHYL ESTER

Chemical Property of DL-NORLEUCINE METHYL ESTER

Chemical Property:

• Boiling Point: 175.4±13.0 °C(Predicted)
• PKA: 7.92±0.35(Predicted)
• PSA: 52.32000
• Density: 0.957±0.06 g/cm3(Predicted)
• LogP: 1.37720

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DL-NORLEUCINE METHYL ESTER

There total 1 articles about DL-NORLEUCINE METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ caprolactam (105-60-2,9012-16-2) + methyl 2-aminohexanoate (51220-79-2)

Guidance literature:

Reference yield:

methyl 2-aminohexanoate (51220-79-2) → L-Norleucine (327-57-1) + L-norleucine methyl ester (21754-55-2) + norleucine methyl ester (119490-22-1)

Guidance literature:

With Alcalase; water; In tert-butyl alcohol; at 25 ℃; for 4h; pH=8.5; Title compound not separated from byproducts;

DOI:10.1002/jccs.199900046

Reference yield:

methyl 2-aminohexanoate (51220-79-2) + 4-Nitrobenzenesulfonyl chloride (98-74-8) → methyl 5-bromo-2-((4-nitrophenyl)sulfonamido)hexanoate

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

2: trimethylsilylazide; N-Bromosuccinimide; 1,10-Phenanthroline; copper(II) trifluoroacetate hydrate name... / 1,2-dichloro-ethane / 18 h / 60 °C

With N-Bromosuccinimide; 1,10-Phenanthroline; trimethylsilylazide; triethylamine; copper(II) trifluoroacetate hydrate name...; In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1002/anie.201608210

Downstream raw materials:

L-Norleucine

L-norleucine methyl ester

norleucine methyl ester

Refernces