7-Bromoquinoline-2-carboxylic acid

Base Information

• Chemical Name: 7-Bromoquinoline-2-carboxylic acid
• CAS No.: 1057217-63-6
• Molecular Formula: C₁₀H₆BrNO₂
• Molecular Weight: 252.067
• Hs Code.: 2933499090
• Mol file: 1057217-63-6.mol

Synonyms:7-BroMoquinoline-2-carboxylic acid

Chemical Property of 7-Bromoquinoline-2-carboxylic acid

Chemical Property:

• Melting Point: 192-198°C
• PSA: 50.19000
• LogP: 2.69550
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

7-Bromoquinoline-2-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Bromoquinoline-2-carboxylic acid

There total 1 articles about 7-Bromoquinoline-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-4-bromobenzaldehyde (59278-65-8) + piruvate (57-60-3) → 7-bromoquinoline-2-carboxylic acid (1057217-63-6)

Guidance literature:

With Pseudomonas putida trans-o-hydroxybenzylidenepyruvate hydratase-aldolase; In aq. phosphate buffer; dimethyl sulfoxide; at 20 ℃; for 16h; pH=6.5; Enzymatic reaction;

DOI:10.1021/acscatal.1c01398

Reference yield:

7-bromoquinoline-2-carboxylic acid (1057217-63-6) + C17H23N3O4*ClH → C27H27BrN4O5

Guidance literature:

7-bromoquinoline-2-carboxylic acid; C₁₇H₂₃N₃O₄*ClH; With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at -20 ℃; for 0.5h;

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -20 ℃; for 12h;

DOI:10.1021/acs.jmedchem.0c02258

Reference yield:

7-bromoquinoline-2-carboxylic acid (1057217-63-6) → C17H12BrNO2

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 0 - 20 °C

2: triethylamine / dichloromethane / 1 h / 20 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;

upstream raw materials:

2-amino-4-bromobenzaldehyde

piruvate

Downstream raw materials:

7-bromoquinoline-2-carbaldehyde

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