N2-Cyclopropyl-4-methyl-2,3-pyridinediamine

Base Information

• Chemical Name: N2-Cyclopropyl-4-methyl-2,3-pyridinediamine
• CAS No.: 284686-18-6
• Molecular Formula: C₉H₁₃N₃
• Molecular Weight: 163.222
• DSSTox Substance ID: DTXSID00444627
• Nikkaji Number: J1.307.781I
• Wikidata: Q82262813
• Mol file: 284686-18-6.mol

Synonyms:N2-Cyclopropyl-4-methyl-2,3-pyridinediamine;284686-18-6;2-N-cyclopropyl-4-methylpyridine-2,3-diamine;AGN-PC-0NABS7;DTXSID00444627;TQP0102;AKOS013558944;N-Cyclopropyl-4-methylpyridine-2,3-diamine;FT-0665404;N2-Cyclopropyl-4-methylpyridine-2,3-diamine

Chemical Property of N2-Cyclopropyl-4-methyl-2,3-pyridinediamine

Chemical Property:

• PSA: 50.94000
• LogP: 2.20070
• Solubility.: Methanol
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 163.110947427
• Heavy Atom Count: 12
• Complexity: 156

Purity/Quality:

97% ^*data from raw suppliers

N2-Cyclopropyl-4-methyl-2,3-pyridinediamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(C(=NC=C1)NC2CC2)N

Technology Process of N2-Cyclopropyl-4-methyl-2,3-pyridinediamine

There total 2 articles about N2-Cyclopropyl-4-methyl-2,3-pyridinediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-(cyclopropylamino)-4-methyl-3-nitropyridine (284686-17-5) → 3-amino-2-cyclopropylamino-4-methylpyridine (284686-18-6)

Guidance literature:

2-(cyclopropylamino)-4-methyl-3-nitropyridine; With hydrogenchloride; tin(II) chloride dihdyrate; acetic acid; In water; at 20 ℃;

With sodium hydroxide; In water; pH=12; Cooling with ice;

DOI:10.3762/bjoc.5.36

Reference yield:

2-chloro-3-nitro-4-methylpyridine (23056-39-5) → 3-amino-2-cyclopropylamino-4-methylpyridine (284686-18-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / xylene / 48 h / 75 °C

2: 55 percent / H₂ / Raney Ni / ethanol / 4 h / 2068.59 Torr

With hydrogen; nickel; In ethanol; xylene; 1: Substitution / 2: Reduction;

DOI:10.1002/jhet.5570370203

Reference yield: 71.0%

2-Chloronicotinoyl chloride (49609-84-9) + 3-amino-2-cyclopropylamino-4-methylpyridine (284686-18-6) → 2-chloro-N-[(2'-cyclopropylamino)-4'-methyl-3'-pyridyl]-3-pyridinecarboxamide (284686-19-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ethyl acetate; at 20 ℃; for 18h;

DOI:10.1002/jhet.5570370203

upstream raw materials:

2-(cyclopropylamino)-4-methyl-3-nitropyridine

2-chloro-3-nitro-4-methylpyridine

Downstream raw materials:

2-chloro-N-[(2'-cyclopropylamino)-4'-methyl-3'-pyridyl]-3-pyridinecarboxamide

2-chloro-N-[(2'-cyclopropylamino)-4'-methyl-3'-pyridyl]-8-nitro-3-pyridinecarboxamide

11-cyclopropyl-5,11-dihydro-3-formyl-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one

3-bromo-11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one