benzyl 2-benzyl-4-chloro-8,9-dihydro-5H-pyriMido[4,5-d]azepine-7(6H)-carboxylate

Base Information

Chemical Name:benzyl 2-benzyl-4-chloro-8,9-dihydro-5H-pyriMido[4,5-d]azepine-7(6H)-carboxylate
CAS No.:1065113-62-3
Molecular Formula:C23H22ClN3O2
Molecular Weight:407.9
Hs Code.:
Mol file:1065113-62-3.mol

Synonyms:benzyl 2-benzyl-4-chloro-8,9-dihydro-5H-pyriMido[4,5-d]azepine-7(6H)-carboxylate;4-Chloro-5,6,8,9-tetrahydro-2-(phenylmethyl)-7H-pyrimido[4,5-d]azepine-7-carboxylic acid phenylmethyl ester

Suppliers and Price of benzyl 2-benzyl-4-chloro-8,9-dihydro-5H-pyriMido[4,5-d]azepine-7(6H)-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
Benzyl 2-benzyl-4-chloro-8,9-dihydro-5H-pyrimido[4,5-d]azepine-7(6H)-carboxylate 95%
250mg
$ 370.00

Matrix Scientific
Benzyl 2-benzyl-4-chloro-8,9-dihydro-5H-pyrimido[4,5-d]azepine-7(6H)-carboxylate 95%
1g
$ 1110.00

Crysdot
Benzyl2-benzyl-4-chloro-8,9-dihydro-5H-pyrimido[4,5-d]azepine-7(6H)-carboxylate 97%
1g
$ 1110.00

Crysdot
Benzyl2-benzyl-4-chloro-8,9-dihydro-5H-pyrimido[4,5-d]azepine-7(6H)-carboxylate 97%
100mg
$ 278.00

Total 2 raw suppliers

Chemical Property of benzyl 2-benzyl-4-chloro-8,9-dihydro-5H-pyriMido[4,5-d]azepine-7(6H)-carboxylate

Chemical Property:

PSA：55.32000
Density:1.269
LogP:4.39610

Purity/Quality:

99% ^*data from raw suppliers

Benzyl 2-benzyl-4-chloro-8,9-dihydro-5H-pyrimido[4,5-d]azepine-7(6H)-carboxylate 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of benzyl 2-benzyl-4-chloro-8,9-dihydro-5H-pyriMido[4,5-d]azepine-7(6H)-carboxylate

There total 5 articles about benzyl 2-benzyl-4-chloro-8,9-dihydro-5H-pyriMido[4,5-d]azepine-7(6H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1065113-59-8
benzyl 2-benzyl-4-oxo-5,6,8,9-tetrahydro-7H-pyrimido[4,5-d]azepine-7-carboxylate

: 1065113-62-3
benzyl 2-benzyl-4-chloro-5,6,8,9-tetrahydro-7H-pyrimido[4,5-d]azepine-7-carboxylate

Guidance literature:: With trichlorophosphate;
DOI:10.1016/j.bmcl.2009.07.063

Reference yield:

: 31696-09-0
1-benzyl 4-ethyl 5-oxoazepane-1,4-dicarboxylate

: 1065113-62-3
benzyl 2-benzyl-4-chloro-5,6,8,9-tetrahydro-7H-pyrimido[4,5-d]azepine-7-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium methylate / methanol / 1 h / 25 °C

2: N-ethyl-N,N-diisopropylamine; trichlorophosphate / acetonitrile / 1.5 h / 70 °C

With sodium methylate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol; acetonitrile;
DOI:10.1021/jm5003292

Reference yield:

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 1065113-62-3
benzyl 2-benzyl-4-chloro-5,6,8,9-tetrahydro-7H-pyrimido[4,5-d]azepine-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron trifluoride diethyl etherate / tert-butyl methyl ether / 0.42 h / -25 - -20 °C

1.2: 2 h / -20 °C

2.1: sodium methylate / methanol / 1 h / 25 °C

3.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / acetonitrile / 1.5 h / 70 °C

With boron trifluoride diethyl etherate; sodium methylate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol; tert-butyl methyl ether; acetonitrile;
DOI:10.1021/jm5003292