benzyl 2-benzyl-4-oxo-5,6,8,9-tetrahydro-7H-pyrimido[4,5-d]azepine-7-carboxylate

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Chemical Name:benzyl 2-benzyl-4-oxo-5,6,8,9-tetrahydro-7H-pyrimido[4,5-d]azepine-7-carboxylate
CAS No.:1065113-59-8
Molecular Formula:C₂₃H₂₃N₃O₃
Molecular Weight:389.454
Hs Code.:

Synonyms:benzyl 2-benzyl-4-oxo-5,6,8,9-tetrahydro-7H-pyrimido[4,5-d]azepine-7-carboxylate

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Chemical Property of benzyl 2-benzyl-4-oxo-5,6,8,9-tetrahydro-7H-pyrimido[4,5-d]azepine-7-carboxylate

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Technology Process of benzyl 2-benzyl-4-oxo-5,6,8,9-tetrahydro-7H-pyrimido[4,5-d]azepine-7-carboxylate

There total 4 articles about benzyl 2-benzyl-4-oxo-5,6,8,9-tetrahydro-7H-pyrimido[4,5-d]azepine-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 31696-09-0
1-benzyl 4-ethyl 5-oxoazepane-1,4-dicarboxylate

: 5504-24-5
2-phenylacetamidine

: 1065113-59-8
benzyl 2-benzyl-4-oxo-5,6,8,9-tetrahydro-7H-pyrimido[4,5-d]azepine-7-carboxylate

Guidance literature:: In methanol;
DOI:10.1016/j.bmcl.2009.07.063

Reference yield: 82.0%

: 623-73-4
diazoacetic acid ethyl ester

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: phenylacetamide hydrochloride

: 1065113-59-8
benzyl 2-benzyl-4-oxo-5,6,8,9-tetrahydro-7H-pyrimido[4,5-d]azepine-7-carboxylate

Guidance literature:: benzyl 4-oxo-1-piperidinecarboxylate; With boron trifluoride diethyl etherate; In tert-butyl methyl ether; at -25 - -20 ℃; for 0.416667h;

diazoacetic acid ethyl ester; In tert-butyl methyl ether; at -20 - 0 ℃; for 2.75h;

phenylacetamide hydrochloride; With water; sodium methylate; potassium carbonate; more than 3 stages; Product distribution / selectivity;