Piperazine, 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)- (acetate)

Base Information

• Chemical Name: Piperazine, 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)- (acetate)
• CAS No.: 906093-30-9
• Molecular Formula: C16H22N4O2
• Molecular Weight: 302.376
• Mol file: 906093-30-9.mol

Synonyms:Piperazine, 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)- (acetate);1-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazine acetate;1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine monoacetate

Chemical Property of Piperazine, 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)- (acetate)

Chemical Property:

• PSA: 70.39000
• LogP: 2.07500

Purity/Quality:

98%min ^*data from raw suppliers

Piperazine,1-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Piperazine, 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)- (acetate)

There total 9 articles about Piperazine, 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)- (acetate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazine-1-carboxylate + acetic acid (64-19-7,77671-22-8) → 1-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazine acetate (906093-30-9)

Guidance literature:

ethyl 4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazine-1-carboxylate; With water; potassium hydroxide; In methanol; at 80 - 85 ℃;

acetic acid; In toluene; at 50 - 55 ℃; for 1h;

Reference yield:

1-tert-butoxycarbonyl-4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazine + acetic acid (64-19-7,77671-22-8) → 1-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazine acetate (906093-30-9)

Guidance literature:

1-tert-butoxycarbonyl-4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazine; With trifluoroacetic acid; In dichloromethane; at 25 - 30 ℃; for 1.5h;

acetic acid; In toluene; at 0 - 5 ℃;

Reference yield:

1-Phenyl-3-methyl-5-aminopyrazole (1131-18-6) + bis-(2-chloroethyl)amine hydrochloride (821-48-7) + acetic acid (64-19-7,77671-22-8) → 1-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazine acetate (906093-30-9)

Guidance literature:

1-Phenyl-3-methyl-5-aminopyrazole; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 5 ℃; for 0.5h;

bis-(2-chloroethyl)amine hydrochloride; In N,N-dimethyl-formamide; at 0 - 30 ℃;

acetic acid; In toluene; at 0 - 5 ℃; for 2h;

upstream raw materials:

acetic acid

phenylhydrazine

1-Phenyl-3-methyl-5-aminopyrazole

bis-(2-chloroethyl)amine hydrochloride

Downstream raw materials:

tert-butyl (2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-2-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidine-1-carboxylate

3-{(2S,4S)-1-(1,1-dimethylethyloxycarbonyl)-4-[4-(3-methyl-1-phenyl-1H-pyrazole-5-yl)piperazin-1-yl]pyrrolidine-2-ylcarbonyl}thiazolidine