Technology Process of (4-CHLORO-2-HYDROXY-6-METHYLPHENYL)BORONIC ACID
There total 7 articles about (4-CHLORO-2-HYDROXY-6-METHYLPHENYL)BORONIC ACID which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(4-chloro-2-methoxy-6-methylphenyl)-4,4,5,5-tetramethyl[1,3,2]dioxaborolane;
With
boron tribromide;
In
dichloromethane;
at 0 ℃;
for 0.166667h;
With
water;
In
dichloromethane;
Cooling;
DOI:10.1021/jm200128m
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: iron; ammonium chloride / ethanol; water / 0.5 h / Reflux
2.1: sulfuric acid; acetic acid; sodium nitrite / 0.5 h / 23 °C
2.2: Reflux
3.1: potassium carbonate / acetonitrile / 12 h / 23 °C
4.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; triethylamine / acetonitrile / 3 h / Reflux
5.1: boron tribromide / dichloromethane / 0.17 h / 0 °C
5.2: Cooling
With
palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sulfuric acid; boron tribromide; iron; potassium carbonate; ammonium chloride; acetic acid; triethylamine; sodium nitrite;
In
ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm200128m
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / acetonitrile / 12 h / 23 °C
2.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; triethylamine / acetonitrile / 3 h / Reflux
3.1: boron tribromide / dichloromethane / 0.17 h / 0 °C
3.2: Cooling
With
palladium bis[bis(diphenylphosphino)ferrocene] dichloride; boron tribromide; potassium carbonate; triethylamine;
In
dichloromethane; acetonitrile;
DOI:10.1021/jm200128m
