5-CarbaMoyl-1-Methyl-2-picoliniuM Iodide

Base Information

• Chemical Name: 5-CarbaMoyl-1-Methyl-2-picoliniuM Iodide
• CAS No.: 107971-06-2
• Molecular Formula: C₈H₁₁N₂O*I
• Molecular Weight: 278.093
• Mol file: 107971-06-2.mol

Synonyms:3-(AMinocarbonyl)-1,6-diMethyl-pyridiniuM Iodide;5-CarbaMoyl-1-Methyl-2-picoliniuM Iodide

Chemical Property of 5-CarbaMoyl-1-Methyl-2-picoliniuM Iodide

Chemical Property:

• PSA: 50.79000
• LogP: 1.67330
• Storage Temp.: -20°C Freezer
• Solubility.: D2O

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-(Aminocarbonyl)-1,6-dimethyl-pyridiniumIodide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A nicotinamide derivative. Intermediate in the synthesis of nudiflorine.

Technology Process of 5-CarbaMoyl-1-Methyl-2-picoliniuM Iodide

There total 4 articles about 5-CarbaMoyl-1-Methyl-2-picoliniuM Iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

6-methylnicotinamide (6960-22-1) + methyl iodide (74-88-4) → 3-aminocarbonyl-1,6-dimethylpyridinium iodide (107971-06-2)

Guidance literature:

In various solvent(s); for 4h; Heating;

Reference yield:

2-methyl-5-vinylpyridine (140-76-1,25038-86-2) → 3-aminocarbonyl-1,6-dimethylpyridinium iodide (107971-06-2)

Guidance literature:

Multi-step reaction with 4 steps

1: KMnO₄, KOH / acetone; H₂O / 2 h / 30 °C

2: Heating

3: 76 percent / saturated aq. NH₃ / 24 h / Ambient temperature

4: methanol

With potassium hydroxide; ammonium hydroxide; potassium permanganate; In methanol; water; acetone;

Reference yield:

6-methylnicotinic acid (3222-47-7) → 3-aminocarbonyl-1,6-dimethylpyridinium iodide (107971-06-2)

Guidance literature:

Multi-step reaction with 3 steps

1: Heating

2: 76 percent / saturated aq. NH₃ / 24 h / Ambient temperature

3: methanol

With ammonium hydroxide; In methanol;

upstream raw materials:

6-methylnicotinamide

methyl iodide

2-methyl-5-vinylpyridine

6-methylnicotinic acid

Downstream raw materials:

1-methyl-2-pyridone-5-carboxamide

Refernces

• 1、 Angelino, S.A.G.F.,Buurman, D.J.,Plas, H.C. van der,Mueller, F.. "The use of immobilized enzymes in organic synthesis. Part 6. Oxidation of 1-alkyl-3-carbamoylpyridinium chlorides by rabbit liver aldehyde oxidase". . p. 342 - 346. Retrieved 2007/10/02.