6960-22-1

Usage

Uses

Used in Pharmaceutical and Chemical Research:
6-METHYLNICOTINAMIDE is used as a research compound for studying the early symptoms of Parkinson's disease, given its toxic effects on rat B65 neuroblastoma cells. This application aids in understanding the underlying mechanisms and potential therapeutic interventions for the condition.
Used in Mitochondrial Function Studies:
As a nicotinamide derivative that inhibits state 3 respiration in isolated rat liver mitochondria, 6-METHYLNICOTINAMIDE serves as a valuable tool in investigating mitochondrial function and energy production within cells.
Used in Chemical Synthesis Studies:
6-METHYLNICOTINAMIDE may also be employed in chemical synthesis studies, potentially leading to the development of novel compounds with various applications in different industries.

InChI:InChI=1/C7H8N2O/c1-5-2-3-6(4-9-5)7(8)10/h2-4H,1H3,(H2,8,10)

Upstream product

• 21684-59-3 ethyl 6-methylnicotinate 
• 5470-70-2 Methyl 6-methylnicotinate 
• 3222-47-7 6-methylnicotinic acid 
• 140-76-1 2-methyl-5-vinylpyridine 
• 67-56-1 methanol 
• 98-92-0 nicotinamide 

Downstream Products

• 96551-72-3 1-benzyl-3-carboxamido-6-methylpyridinium bromide 
• 127663-06-3 1-(4-methylbenzyl)-3-carbamoyl-6-methylpyridinium bromide 
• 127678-20-0 1-(4-bromobenzyl)-3-carbamoyl-6-methylpyridinium bromide 
• 127663-05-2 1-(4-methoxybenzyl)-3-carbamoyl-6-methylpyridinium chloride 
• 127663-07-4 1-(4-cyanobenzyl)-3-carbamoyl-6-methylpyridinium bromide 
• 107971-06-2 3-aminocarbonyl-1,6-dimethylpyridinium iodide 
• 258834-90-1 6-O-tert-butyldimethylsilyl-1-(5-carboxamido-2-pyridyl)-1,2,5-trideoxy-2,5-imino-3,4-O-isopropylidene-D-allitol 
• 91999-49-4 6-Methyl-1-(2',6'-Dichlorobenzyl)-1,4-dihydronicotinamide 
• 20557-70-4 1-Benzyl-6-methyl-1,4-dihydro-pyridine-3-carboxylic acid amide 
• 702-16-9 5-butyl-2-methylpyridine 
• 916585-90-5 3-(3-amino-5-chloro-2,6-diethyl-phenyl)-1-(4-ethyl-phenyl)-1-(6-methyl-pyridin-3yl-methyl)-urea 
• 916587-13-8 (4-ethyl-phenyl)-(6-methyl-pyridin-3-ylmethyl)-amine 
• 13061-58-0 4,6-dimethyl-3-pyridinecarboxamide 
• 56622-54-9 C-(6-methylpyridin-3-yl)methylamine 

Relevant academic research and scientific papers

SIMULTANEOUS PARTICIPATION OF SEVERAL EXCITED STATES IN PHOTOCHEMICAL METHOXYLATION AND METHYLATION OF 3-PYRIDINECARBOXAMIDE IN METHANOL

The UV-irradiation of 3-pyridinecarboxamide in methanol in the presence of sulfuric acid brings about methoxylation (ionic reaction) at the 2- and 6-position and methylation (radical reaction) at the 4- and 6-position.The effects of quenchers indicate that two methylation products originate from one excited triplet state which is quenched by energy transfer mechanism and that two methoxylation products originate from two different excited singlet states which are quenched by electron transfer mechanism.

Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase

Nicotinamide N-methyltransferase (NNMT) has been linked to obesity and diabetes. We have identified a novel nicotinamide (NA) analog, compound 12 that inhibited NNMT enzymatic activity and reduced the formation of 1-methyl-nicotinamide (MNA), the primary metabolite of NA by ～80% at 2 h when dosed in mice orally at 50 mg/kg.

Acid secretion inhibitor

The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl group, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.

FIVE-MEMBERED HETEROCYCLIC DERIVATIVE

The present invention relates to a compound represented by formula (I): a salt of the compound, or a solvate of the compound or the salt; a drug containing any of the compounds, the salts, and the solvates; a preventive and/or therapeutic agent for an ischemic disease containing any of the compounds, the salts, and the solvates; and a platelet coagulation inhibitor containing any of the compounds, the salts, and the solvates. The compound of the present invention is useful as a strong platelet coagulation inhibitor without inhibiting COX-1 or COX-2.

Bioisosteres of arecoline: 1,2,3,6-Tetrahydro-5-pyridyl-substituted and 3- piperidyl-substituted derivatives of tetrazoles and 1,2,3-triazoles. Synthesis and muscarinic activity

A series of arecoline bioisosteres, where the ester group is replaced by a 1,2,3-triazol-4-yl or a tetrazol-5-yl group, was synthesized and evaluated in vitro for affinity and efficacy at muscarinic receptors and in vivo for cholinergic side effects. The corresponding piperidine derivatives were also studied. In the 1,2,3,6-tetrahydropyridyl-1,2,3-triazole series, only derivatives with 2-substituents in the 1,2,3-triazole ring exert muscarinic agonist activity. The same trend is seen in the corresponding tetrazole series, where only 2-substituted derivatives display muscarinic agonist activity. The methyl derivatives in both series are full agonists, whereas the derivatives with longer side chains are partial agonists. Introduction of methyl substituents in the 1,2,3,6-tetrahydropyridine ring generally lowers affinity considerably except for the 3-substituted derivatives, where some activity is retained. In both the 1,2,3-triazole and tetrazole series, derivatives without substituents at the basic nitrogen in the 1,2,3,6- tetrahydropyridine ring are unselective full agonists, whereas the methyl- substituted derivatives generally are more M1 selective compared to M2. Larger substituents than methyl abolish activity. The 4-(3-piperidyl)-1,2,3- triazole and 5-(3-piperidyl)-2H-tetrazole derivatives are generally less active than the corresponding 1,2,3,6-tetrahydropyridine derivatives, and only the 2-allyl- and 2-propargyl-1,2,3-triazole derivatives display activities comparable to the most active compounds in the 1,2,3,6- tetrahydropyridine series. The propargyl derivative is an unselective full agonist, and resolution did not reveal any stereoselectivity. The allyl derivative is a partial agonist with some selectivity for the M1 receptor, and testing of the enantiomers showed that the (+)-enantiomer is an unselective partial agonist, whereas the (-)-enantiomer is a partial agonist with preference for the M1 receptor. Generally, the structure-activity relationships of the 1,2,3-triazole and tetrazole series are very similar, and two compounds, 2-ethyl-4-(1-methyl-1,2,3,6-tetrahydro-5-pyridyl)-1,2,3- triazole and 2-ethyl-5-(1-methyl-l,2,3,6-tetrahydro-5-pyridyl)-2H-tetrazole, are M1 agonists/M2 antagonists. Muscarinic compounds with this profile are of particular interest as drugs for the treatment of Alzheimer's disease.

Photochemical Alkylation, Hydroxyalkylation, and Alkoxylation of Pyridinecarboxamides in Alcohol

The UV-irradiation of 2- and 4-pyridinecarboxamides in alcohol brings about alkylation and/or hydroxyalkylation in the pyridine ring.In the irradiation of 3-pyridinecarboxamide in the presence of sulfuric acid, ionic reaction (alkoxylation at the 2- and 6-position) and radical reaction (alkylation at the 4- and 6-position) occur in parallel.The effects of quenchers indicate that two alkylation products originate from one excited triplet state which is quenched by energy-transfer mechanism and that two alkoxylation products originate from the excited singlet state.

NMR Properties and Synthesis of Ring-methylated 1,4-Dihydronicotinamides and the Corresponding Pyridinium Salts. Correlation of NMR with Ab Initio STO-3G Results

The synthesis of a series of ring-methylated 1-alkyl-1,4-dihydronicotinamides and the corresponding pyridinium salts is described.Their NMR properties involving aromatic-ring-shielding anisotropy, due to ring current effects, are discussed and compared with electron populations calculated from STO-3G results.

Radiation-induced Alkylation, Hydroxyalkylation, and Reduction of Pyridinecarboxamides in Acidic Alcoholic Solutions

The γ-irradiation of pyridinecarboxamides in acidic methanol or ethanol brings about substitution of the ring hydrogen by alkyl or hydroxyalkyl groups derived from the solvent alcohols in relatively high G-values.In 2-propanol, little alkylation and hydroxyalkylation occur and reduction of CONH2 to CH2OH occurs in low G-values.

Inhibiting the growth of weeds with 2-substituted pyrdidopyimidines and salts thereof

2-Substituted pyridopyrimidines and their alkali and alkylamine salts as herbicides, and processes for the synthesis of starting materials leading to the preparation thereof.