7-Chloropyrido[2,3-b]pyrazine

Base Information

• Chemical Name: 7-Chloropyrido[2,3-b]pyrazine
• CAS No.: 116081-22-2
• Molecular Formula: C₇H₄ClN₃
• Molecular Weight: 165.582
• Hs Code.: 2933990090
• Mol file: 116081-22-2.mol

Synonyms:7-Chloropyrido[2,3-b]pyrazine;7-chloropyrido[3

Chemical Property of 7-Chloropyrido[2,3-b]pyrazine

Chemical Property:

• Vapor Pressure: 0.01mmHg at 25°C
• Boiling Point: 273.3°C at 760 mmHg
• Flash Point: 145.388°C
• PSA: 38.67000
• Density: 1.438g/cm³
• LogP: 1.67820
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

7-Chloropyrido[2,3-b]pyrazine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Chloropyrido[2,3-b]pyrazine

There total 3 articles about 7-Chloropyrido[2,3-b]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

5-chloro-2,3-diaminopyridine (25710-20-7) + Glyoxal (131543-46-9,107-22-2) → 7-chloropyrido[2,3-b]pyrazine (116081-22-2)

Guidance literature:

In ethanol; water; for 3h; Reflux;

DOI:10.1007/s10593-020-02628-1

Reference yield:

2-amino-5-chloro-3-nitropyridine (5409-39-2) → 7-chloropyrido[2,3-b]pyrazine (116081-22-2)

Guidance literature:

Multi-step reaction with 2 steps

1: tin(ll) chloride; hydrogenchloride / 1 h / 100 °C

2: water; ethanol / 3 h / Reflux

With hydrogenchloride; tin(ll) chloride; In ethanol; water;

DOI:10.1007/s10593-020-02628-1

Reference yield:

5-chloro-2,3-diaminopyridine (25710-20-7) + glyoxal sodium bisulfite (517-21-5) → 7-chloropyrido[2,3-b]pyrazine (116081-22-2)

Guidance literature:

With ethanol;

DOI:10.1021/jo01092a018 DOI:10.1039/jr9550000303

upstream raw materials:

5-chloro-2,3-diaminopyridine

Glyoxal

glyoxal sodium bisulfite

2-amino-5-chloro-3-nitropyridine

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