8-bromo-5-fluoroquinoline

Base Information

• Chemical Name: 8-bromo-5-fluoroquinoline
• CAS No.: 917251-99-1
• Molecular Formula: C₉H₅BrFN
• Molecular Weight: 226.048
• Hs Code.: 2933499090
• Mol file: 917251-99-1.mol

Synonyms:8-bromo-5-fluoroquinoline

Chemical Property of 8-bromo-5-fluoroquinoline

Chemical Property:

• Boiling Point: 294.2±20.0 °C(Predicted)
• PKA: 1.35±0.29(Predicted)
• PSA: 12.89000
• Density: 1.647±0.06 g/cm3(Predicted)
• LogP: 3.13640
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

8-Bromo-5-fluoroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-bromo-5-fluoroquinoline

There total 4 articles about 8-bromo-5-fluoroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.8%

2-bromo-5-fluoroaniline (1003-99-2) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 8-bromo-5-fluoro-quinoline (917251-99-1)

Guidance literature:

2-bromo-5-fluoroaniline; glycerol; With sulfuric acid; sodium 3-nitrobenzenesulfonate; In water; at 60 - 130 ℃; for 3h;

With sodium hydroxide; In tert-butyl methyl ether; water; Product distribution / selectivity;

Reference yield: 87.5%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + 2-bromo-5-fluoroaniline (1003-99-2) → 8-bromo-5-fluoro-quinoline (917251-99-1)

Guidance literature:

With sulfuric acid; In water; glycerol; at 140 - 150 ℃; for 1.5h; Product distribution / selectivity;

Reference yield: 78.3%

→ 8-bromo-5-fluoro-quinoline (917251-99-1)

Guidance literature:

With sulfuric acid; sodium 3-nitrobenzenesulfonate; at 150 ℃; for 20h;

upstream raw materials:

4-nitro-phenol

2-bromo-5-fluoroaniline

glycerol

Refernces

• 1、 -. "HYDROPYRIDO[1,2-α]PYRAZINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE". Page/Page column 19. . Retrieved 2021/06/11.
• 2、 -. "TRIAZATRICYCLE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE". Page/Page column 19. . Retrieved 2021/05/29.