(S)-1-(imidazo[1,2-a]pyridin-6-yl)ethan-1-amine

Base Information

• Chemical Name: (S)-1-(imidazo[1,2-a]pyridin-6-yl)ethan-1-amine
• CAS No.: 1259603-82-1
• Molecular Formula: C9H11N3
• Molecular Weight: 161.2
• Mol file: 1259603-82-1.mol

Synonyms:(S)-1-(imidazo[1,2-a]pyridin-6-yl)ethan-1-amine;(1S)-1-imidazo[1,2-a]pyridin-6-ylethanamine,hydrochloride

Chemical Property of (S)-1-(imidazo[1,2-a]pyridin-6-yl)ethan-1-amine

Chemical Property:

• PKA: 8.31±0.29(Predicted)
• PSA: 43.32000
• Density: 1.22±0.1 g/cm3(Predicted)
• LogP: 2.05430

Purity/Quality:

99%, ^*data from raw suppliers

(1S)-1-(4-HYDROIMIDAZO[1,2-A]PYRIDIN-6-YL)ETHYLAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-1-(imidazo[1,2-a]pyridin-6-yl)ethan-1-amine

There total 11 articles about (S)-1-(imidazo[1,2-a]pyridin-6-yl)ethan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S)-1-imidazo[1,2-a]pyridin-6-ylethanamine dihydrochloride → (1S)-1-imidazo[1,2-a]pyridin-6-ylethanamine (1259603-82-1,1259780-63-6)

Guidance literature:

With ammonia; In dichloromethane; water; at 10 - 20 ℃;

Reference yield:

C9H9N5 → 1-(imidazo[1,2-a]pyridin-6-yl)ethanamine (1270475-03-0,1259603-82-1,1259780-63-6)

Guidance literature:

With ammonium hydroxide; triphenylphosphine; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jm500510f

Reference yield:

methyl 6-aminonicotinoate (36052-24-1) → 1-(imidazo[1,2-a]pyridin-6-yl)ethanamine (1270475-03-0,1259603-82-1,1259780-63-6)

Guidance literature:

Multi-step reaction with 5 steps

1: water; ethanol / 4 h / Reflux

2: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere

3: tetrahydrofuran / 0 - 20 °C

4: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0 °C

5: ammonium hydroxide; triphenylphosphine / tetrahydrofuran / 20 °C

With ammonium hydroxide; diphenyl phosphoryl azide; isopropylmagnesium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In tetrahydrofuran; ethanol; water;

DOI:10.1021/jm500510f

upstream raw materials:

methyl 6-aminonicotinoate

methyl 6-imidazo<1,2-a>pyridinecarboxylate

imidazo[1,2-a]pyridine-6-carboxylic acid methoxy(methyl)amide

1-(imidazo[1,2-a]pyridin-6-yl)ethanone

Downstream raw materials:

(R)-1-(1-(imidazo[1,2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine

savolitinib