1-IMidazo[1,2-a]pyridin-6-ylethanone

Base Information

• Chemical Name: 1-IMidazo[1,2-a]pyridin-6-ylethanone
• CAS No.: 944905-12-8
• Molecular Formula: C₉H₈N₂O
• Molecular Weight: 160.175
• Hs Code.: 2933998090
• Mol file: 944905-12-8.mol

Synonyms:1-IMidazo[1,2-a]pyridin-6-ylethanone;1-(imidazo[1,2-a]pyridin-6-yl)ethan-1-one

Chemical Property of 1-IMidazo[1,2-a]pyridin-6-ylethanone

Chemical Property:

• PKA: 5.14±0.50(Predicted)
• PSA: 34.37000
• Density: 1.21±0.1 g/cm3(Predicted)
• LogP: 1.53690
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

1-Imidazo[1,2-a]pyridin-6-yl-ethanone 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-IMidazo[1,2-a]pyridin-6-ylethanone

There total 5 articles about 1-IMidazo[1,2-a]pyridin-6-ylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

imidazo[1,2-a]pyridine-6-carboxylic acid methoxy(methyl)amide (1313726-20-3) + methylmagnesium bromide (75-16-1) → 1-(imidazo[1,2-a]pyridin-6-yl)ethanone (944905-12-8)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/jm500510f

Reference yield:

6-aminonicotinic acid (3167-49-5) → 1-(imidazo[1,2-a]pyridin-6-yl)ethanone (944905-12-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: water / 4 h / 75 - 80 °C / Large scale

2.1: 1,1'-carbonyldiimidazole / acetonitrile / 16 h / 10 - 20 °C / Large scale

2.2: 24 h / 5 - 12 °C / Large scale

3.1: tetrahydrofuran / 8 h / 5 - 20 °C / Large scale

With 1,1'-carbonyldiimidazole; In tetrahydrofuran; water; acetonitrile;

Reference yield:

imidazo[1,2-a]pyridine-6-carboxylic acid (139022-25-6) → 1-(imidazo[1,2-a]pyridin-6-yl)ethanone (944905-12-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / acetonitrile / 16 h / 10 - 20 °C / Large scale

1.2: 24 h / 5 - 12 °C / Large scale

2.1: tetrahydrofuran / 8 h / 5 - 20 °C / Large scale

With 1,1'-carbonyldiimidazole; In tetrahydrofuran; acetonitrile;

upstream raw materials:

imidazo[1,2-a]pyridine-6-carboxylic acid methoxy(methyl)amide

methylmagnesium bromide

methyl 6-aminonicotinoate

methyl 6-imidazo<1,2-a>pyridinecarboxylate

Downstream raw materials:

1-(imidazo[1,2-a]pyridin-6-yl)ethanamine

(R)-1-(1-(imidazo[1,2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine

savolitinib

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