rac-cis-1-Benzyl-2-methyl-4-(N-propananilido)piperidine

Base Information

• Chemical Name: rac-cis-1-Benzyl-2-methyl-4-(N-propananilido)piperidine
• CAS No.: 79278-40-3
• Molecular Formula: C₂₂H₂₈N₂O
• Molecular Weight: 336.477
• Mol file: 79278-40-3.mol

Synonyms:rac-cis-1-Benzyl-2-methyl-4-(N-propananilido)piperidine;(+/-)-cis-N-[2-Methyl-1-(phenylMethyl)-4-piperidinyl]-N-phenyl-propanaMide

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Chemical Property of rac-cis-1-Benzyl-2-methyl-4-(N-propananilido)piperidine

Chemical Property:

• PSA: 23.55000
• LogP: 4.27810

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of rac-cis-1-Benzyl-2-methyl-4-(N-propananilido)piperidine

There total 8 articles about rac-cis-1-Benzyl-2-methyl-4-(N-propananilido)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Benzyl-3-methyl-4-piperidon (34737-89-8) → cis-N-<3-methyl-1-(phenylmethyl)-4-piperidinyl>-N-phenylpropanamide (42045-84-1,79278-40-3,79278-41-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 5 N HCl, sodium cyanoborohydride, 3 A molecular sieves / methanol / 72 h / Ambient temperature

2: 3.5 g / 4 h / Heating

With hydrogenchloride; 3 A molecular sieve; sodium cyanoborohydride; In methanol;

Reference yield:

1-Benzyl-3-methyl-4-piperidon (34737-89-8) → trans-N-<3-methyl-1-(phenylmethyl)-4-piperidinyl>-N-phenylpropanamide (42045-84-1,79278-40-3,79278-41-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 5 N HCl, sodium cyanoborohydride, 3 A molecular sieves / methanol / 72 h / Ambient temperature

2: 3 h / Heating

With hydrogenchloride; 3 A molecular sieve; sodium cyanoborohydride; In methanol;

Reference yield:

aniline (62-53-3) → trans-N-<3-methyl-1-(phenylmethyl)-4-piperidinyl>-N-phenylpropanamide (42045-84-1,79278-40-3,79278-41-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 5 N HCl, sodium cyanoborohydride, 3 A molecular sieves / methanol / 72 h / Ambient temperature

2: 3 h / Heating

With hydrogenchloride; 3 A molecular sieve; sodium cyanoborohydride; In methanol;

upstream raw materials:

(+/-)-trans-1-benzyl-3-methyl-N-phenylpiperidinamine

propionic acid anhydride

1-Benzyl-3-methyl-4-piperidon

1-benzyl-3-methyl-4-phenyliminopiperidine

Downstream raw materials:

trans-N-<3-methyl-4-piperidinyl>-N-phenylpropanamide

trans-N-(3-methyl-1-<2-(1,2,3,4-tetrahydro)naphthyl>-4-piperidinyl)-N-phenylpropanamide

cis-N-<3-methyl-4-piperidinyl>-N-phenylpropanamide

cis-N-(3-methyl-1-<2-(1,2,3,4-tetrahydro)naphthyl>-4-piperidinyl)-N-phenylpropanamide