4-Hydrazinyl-8-methylquinoline

Base Information

• Chemical Name: 4-Hydrazinyl-8-methylquinoline
• CAS No.: 68500-35-6
• Molecular Formula: C₁₀H₁₁N₃
• Molecular Weight: 173.217
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID70498470
• Wikidata: Q82348535
• Mol file: 68500-35-6.mol

Synonyms:4-Hydrazino-8-methylquinoline;68500-35-6;4-HYDRAZINYL-8-METHYLQUINOLINE;(8-methylquinolin-4-yl)hydrazine;DTXSID70498470;MFCD00272470;AKOS002683770;AB05750;BS-36234;BB 0263524;FT-0618606

Chemical Property of 4-Hydrazinyl-8-methylquinoline

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 391.148°C at 760 mmHg
• Flash Point: 190.36°C
• PSA: 50.94000
• Density: 1.24g/cm³
• LogP: 2.60210
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 173.095297364
• Heavy Atom Count: 13
• Complexity: 172

Purity/Quality:

98.5% ^*data from raw suppliers

4-hydrazino-8-methylquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C2C(=CC=C1)C(=CC=N2)NN

Technology Process of 4-Hydrazinyl-8-methylquinoline

There total 3 articles about 4-Hydrazinyl-8-methylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-8-methylquinoline (18436-73-2) → 4-hydrazino-8-methyl-quinoline (68500-35-6)

Guidance literature:

With hydrazine; In diethylene glycol; at 90 - 100 ℃; for 1h;

DOI:10.5935/0103-5053.20140062

Reference yield:

8-methylquinolin-4-ol (23432-44-2) → 4-hydrazino-8-methyl-quinoline (68500-35-6)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 24 h / Reflux

2: hydrazine / diethylene glycol / 1 h / 90 - 100 °C

With hydrazine; trichlorophosphate; In diethylene glycol;

DOI:10.5935/0103-5053.20140062

Reference yield:

→ 4-hydrazino-8-methyl-quinoline (68500-35-6)

Guidance literature:

Entspr. 4-Chlorchinolin, Hydrazinhydrat (915, 920);

upstream raw materials:

8-methylquinolin-4-ol

4-chloro-8-methylquinoline

Downstream raw materials:

4-methyl-N-(2-methyl-6-{1-[(4-methylphenyl)sulfonyl]-1Hpyrazol-3-yl}phenyl)benzenesulfonamide

N-{2-methyl-6-[1-(phenylsulfonyl)-1H-pyrazol-3-yl]phenyl}benzenesulfonamide

C₁₀H₁₁N₃