23432-44-2

Basic information

• Product Name: 4-HYDROXY-8-METHYLQUINOLINE
• Synonyms: 8-METHYL-4-QUINOLINOL;8-METHYL-4(1H)-QUINOLINONE;8-METHYL-QUINOLIN-4-OL;4-HYDROXY-8-METHYLQUINOLINE;8-Methylquinolin-4(1H)-one;8-Methylquinolin-4-ol, 4-Hydroxy-8-methyl-1-azanaphthalene
• CAS NO: 23432-44-2
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.18
• Mol File: 23432-44-2.mol

Chemical Properties

• Melting Point: 213-215
• Boiling Point: 326.8 °C at 760 mmHg
• Flash Point: 151.4 °C
• Appearance: /
• Density: 1.21 g/cm³
• Vapor Pressure: 0.000111mmHg at 25°C
• Refractive Index: 1.666
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 4.47±0.40(Predicted)
• CAS DataBase Reference: 4-HYDROXY-8-METHYLQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-8-METHYLQUINOLINE(23432-44-2)
• EPA Substance Registry System: 4-HYDROXY-8-METHYLQUINOLINE(23432-44-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 23432-44-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-HYDROXY-8-METHYLQUINOLINE is used as an intermediate in the production of various pharmaceuticals for its role in the synthesis of antimalarial and antifungal drugs.
Used in Dye Synthesis:
4-HYDROXY-8-METHYLQUINOLINE is used as a component in the synthesis of dyes, contributing to the development of colorants for various applications.
Used as a Chelating Agent:
4-HYDROXY-8-METHYLQUINOLINE is used as a chelating agent for metal ions, facilitating the binding and separation of metal ions in various chemical processes.
Used in Analytical Chemistry:
4-HYDROXY-8-METHYLQUINOLINE is used as a reagent for the determination of certain metal ions in solution, aiding in the analysis and quantification of metal content in various samples.

InChI:InChI=1/C10H9NO/c1-7-3-2-4-8-9(12)5-6-11-10(7)8/h2-6H,1H3,(H,11,12)

Upstream product

• 19146-73-7 diethyl 2-((o-tolylamino)methylene)malonate 
• 77156-75-3 4-hydroxy-8-methyl-quinoline-3-carboxylic acid ethyl ester 
• 25253-09-2 5-{[(2-methylphenyl)amino]methylene}-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 35966-17-7 4-hydroxy-8-methyl-quinoline-3-carboxylic acid 
• 36053-94-8 8-methyl-2,3-dihydro-1H-quinolin-4-one 

Downstream Products

• 816448-09-6 8-methylquinoline-4-carboxylic acid 
• 1593934-90-7 methyl 8-methylquinoline-4-carboxylate 
• 36075-68-0 4-bromo-8-methylquinoline 
• 1082748-36-4 C₁₀H₁₁N₃ 
• 1621083-00-8 N-{2-methyl-6-[1-(phenylsulfonyl)-1H-pyrazol-3-yl]phenyl}benzenesulfonamide 
• 68500-35-6 4-hydrazino-8-methyl-quinoline 
• 1621082-94-7 4-methyl-N-(2-methyl-6-{1-[(4-methylphenyl)sulfonyl]-1Hpyrazol-3-yl}phenyl)benzenesulfonamide 
• 18436-73-2 4-chloro-8-methylquinoline 
• 611-32-5 8-methylquinoline 

Relevant articles and documents

Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities

A simple two-step synthesis method was used to make 51 B-ring-substituted 4-hydroxyquinolines allowing analysis of the effect of ring substitutions on inhibition of growth of chloroquine sensitive and resistant strains of Plasmodium falciparum, the dominant cause of malaria morbidity. Substituted quinoline rings other than the 7-chloroquinoline ring found in chloroquine were found to have significant activity against the drug-resistant strain of P. falciparum W2.

Thioquinolone compounds which have useful pharmaceutical activity

Disclosed is a thioquinolone derivative which exhibits highly selective antibacterial activity against Helicobacter pylori.