18436-73-2

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-8-methylquinoline is used as an intermediate compound for the synthesis of various pharmaceuticals. Its presence in the quinoline family makes it a valuable building block for the development of new drugs, particularly those targeting specific biological pathways or diseases.
Used in Dye Production:
In the chemical industry, 4-Chloro-8-methylquinoline is used as a component in the production of dyes. Its chemical structure allows for the creation of a range of colors, making it a versatile ingredient in the formulation of dyes for textiles, plastics, and other materials.
Used in Disinfectant Formulation:
4-Chloro-8-methylquinoline is also utilized in the formulation of disinfectants. Its antimicrobial properties contribute to the effectiveness of these products, which are essential for maintaining hygiene and preventing the spread of infections in various settings, such as healthcare facilities and households.

InChI:InChI=1/C10H8ClN/c1-7-3-2-4-8-9(11)5-6-12-10(7)8/h2-6H,1H3

Upstream product

• 101-84-8 diphenylether 
• 95-53-4 o-toluidine 
• 23432-44-2 8-methylquinolin-4-ol 
• 25253-09-2 5-{[(2-methylphenyl)amino]methylene}-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 

Downstream Products

• 816448-91-6 4-cyano-8-methylquinoline 
• 1082748-36-4 C₁₀H₁₁N₃ 
• 1621083-00-8 N-{2-methyl-6-[1-(phenylsulfonyl)-1H-pyrazol-3-yl]phenyl}benzenesulfonamide 
• 68500-35-6 4-hydrazino-8-methyl-quinoline 
• 1621082-94-7 4-methyl-N-(2-methyl-6-{1-[(4-methylphenyl)sulfonyl]-1Hpyrazol-3-yl}phenyl)benzenesulfonamide 

Relevant academic research and scientific papers

Synthesis and in vitro evaluation of new benzenesulfonamides as antileishmanial agents

This paper describes the synthesis and the antileishmanial activity of new pyrazolyl benzenesulfonamide derivatives. These were elucidated by spectrometric methods. Some compounds showed a significant in vitro activity against Leishmania amazonensis, highlighting the derivative 1e. These pyrazolyl benzenesulfonamide derivatives did not show any toxicity in murine macrophage.

Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities

A simple two-step synthesis method was used to make 51 B-ring-substituted 4-hydroxyquinolines allowing analysis of the effect of ring substitutions on inhibition of growth of chloroquine sensitive and resistant strains of Plasmodium falciparum, the dominant cause of malaria morbidity. Substituted quinoline rings other than the 7-chloroquinoline ring found in chloroquine were found to have significant activity against the drug-resistant strain of P. falciparum W2.

QUINOLYL AMIDE DERIVATIVES AS CCR-5 ANTAGONISTS

The present invention relates to a series of compounds which are CCR-5 receptor antagonists of the general formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables are defined herein.