3-Ethoxy-2,6-difluorobenzaldehyde

Base Information

• Chemical Name: 3-Ethoxy-2,6-difluorobenzaldehyde
• CAS No.: 1028263-18-4
• Molecular Formula: C9H8F2O2
• Molecular Weight: 186.16
• Hs Code.: 2913000090
• Mol file: 1028263-18-4.mol

Synonyms:3-Ethoxy-2,6-difluorobenzaldehyde

Chemical Property of 3-Ethoxy-2,6-difluorobenzaldehyde

Chemical Property:

• PSA: 26.30000
• LogP: 2.17600

Purity/Quality:

97% ^*data from raw suppliers

3-Ethoxy-2,6-difluorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Ethoxy-2,6-difluorobenzaldehyde

There total 2 articles about 3-Ethoxy-2,6-difluorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-difluoro-4-ethoxybenzene (348-20-9) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-Ethoxy-2,6-difluoro-benzaldehyde (1028263-18-4)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1.) hexane, THF, -65 degC, 0.5 h, 2.) hexane, THF, from -65 deg C to RT;

DOI:10.1021/jm950639r

Reference yield:

2,4-difluorophenol (367-27-1) → 3-Ethoxy-2,6-difluoro-benzaldehyde (1028263-18-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: K₂CO₃ / acetone / 55 °C

2.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -65 °C

2.2: hexane; tetrahydrofuran / -65 - 20 °C

With n-butyllithium; potassium carbonate; In tetrahydrofuran; hexane; acetone; 1.1: ethylation / 2.1: Metallation / 2.2: Formylation;

DOI:10.1021/jm990095j

Reference yield:

Methyltriphenylphosphonium bromide (1779-49-3) + 3-Ethoxy-2,6-difluoro-benzaldehyde (1028263-18-4) → 1-ethoxy-2,4-difluoro-3-vinyl-benzene (1026813-86-4)

Guidance literature:

Methyltriphenylphosphonium bromide; With n-butyllithium; In tetrahydrofuran; hexane; at 20 - 36 ℃;

3-Ethoxy-2,6-difluoro-benzaldehyde; In tetrahydrofuran; hexane; at 45 ℃; for 0.333333h;

DOI:10.1021/jm990095j

upstream raw materials:

1,3-difluoro-4-ethoxybenzene

N,N-dimethyl-formamide

2,4-difluorophenol

Downstream raw materials:

1-Ethoxy-2,4-difluoro-3-((E)-2-nitro-vinyl)-benzene

1-ethoxy-2,4-difluoro-3-vinyl-benzene

2,6-difluoro-3-ethoxyphenethylamine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1028263-18-4 3-Ethoxy-2,6-difluorobenzaldehyde

Send

Send

Metric Ton KG G Pound L ML

Send

Send