Technology Process of 5-(2-bromoacetyl)-4-methylisobenzofuran-1(3H)-one
There total 10 articles about 5-(2-bromoacetyl)-4-methylisobenzofuran-1(3H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetra-N-butylammonium tribromide;
In
dichloromethane;
at 20 ℃;
for 1h;
- Guidance literature:
-
5-(1-butoxy-vinyl)-4-methyl-3H-isobenzofuran-1-one;
With
N-Bromosuccinimide;
In
tetrahydrofuran; water;
at 5 - 20 ℃;
for 0.5h;
With
hydrogen bromide;
In
tetrahydrofuran; water;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: boron trifluoride diethyl etherate; sodium tetrahydroborate / tetrahydrofuran / 4.58 h / 10 - 17 °C
2.1: N-Bromosuccinimide; trifluoroacetic acid / acetonitrile / 0.5 h / -40 - -33 °C / Inert atmosphere
3.1: N,N-dimethyl-formamide / 2 h / 145 °C / Inert atmosphere
3.2: 20 h / 95 °C / Inert atmosphere
4.1: triethylamine / dichloromethane / 1.08 h / 3.8 - 10 °C / Inert atmosphere
5.1: triethylamine; palladium diacetate; 1,3-bis-(diphenylphosphino)propane / N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere
6.1: N-Bromosuccinimide / tetrahydrofuran; water / 0.5 h / 5 - 20 °C
6.2: 1 h / 20 °C
With
sodium tetrahydroborate; N-Bromosuccinimide; boron trifluoride diethyl etherate; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
