2,6-dimethyl-1-phenyl-1H-benzimidazole

Base Information

• Chemical Name: 2,6-dimethyl-1-phenyl-1H-benzimidazole
• CAS No.: 1056894-82-6
• Molecular Formula: C₁₅H₁₄N₂
• Molecular Weight: 0
• Mol file: 1056894-82-6.mol

Synonyms:2,6-dimethyl-1-phenyl-1H-benzimidazole

Chemical Property of 2,6-dimethyl-1-phenyl-1H-benzimidazole

Chemical Property:

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-dimethyl-1-phenyl-1H-benzimidazole

There total 5 articles about 2,6-dimethyl-1-phenyl-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C15H15BrN2 (1195791-10-6,1262283-72-6) → 2,6-dimethyl-1-phenyl-1H-benzo[d]imidazole (1056894-82-6)

Guidance literature:

With copper(II) oxide; potassium hydroxide; In dimethyl sulfoxide; at 110 ℃; for 5h;

DOI:10.1021/jo901813g

Reference yield: 90.0%

C15H15BrN2 (1195791-10-6,1262283-72-6) → 2,6-dimethyl-1-phenyl-1H-benzo[d]imidazole (1056894-82-6)

Guidance literature:

With 1,10-Phenanthroline; bis-acetylacetonatocobalt(II) dihydrate; potassium carbonate; In toluene; at 110 ℃; for 16h;

DOI:10.1039/c0ob00405g

Reference yield: 53.0%

3-bromo-4-iodotoluene (71838-16-9) + N-phenylacetamidine (14277-00-0) → 2,6-dimethyl-1-phenyl-1H-benzo[d]imidazole (1056894-82-6)

Guidance literature:

With copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine; In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 24h; regiospecific reaction; Inert atmosphere;

DOI:10.1002/ejoc.200901056

upstream raw materials:

iodobenzene

2-bromo-4-methylacetanilide

acetamidine hydrochloride

C₁₅H₁₅BrN₂

Refernces

• 1、 Saha, Prasenjit,Ali, Md Ashif,Ghosh, Pokhraj,Punniyamurthy, Tharmalingam. "Cobalt-catalyzed intramolecular C-N and C-O cross-coupling reactions: Synthesis of benzimidazoles and benzoxazoles". experimental part. p. 5692 - 5699. Retrieved 2011/02/18.
• 2、 Yang, Daoshan,Fu, Hua,Hu, Liming,Jiang, Yuyang,Zhao, Yufen. "Copper-catalyzed synthesis of benzimidazoles via cascade reactions of o-haloacetanilide derivatives with amidine hydrochlorides". . p. 7841 - 7844. Retrieved 2008/12/22.