71838-16-9

Basic information

• Product Name: 3-BROMO-4-IODOTOLUENE
• Synonyms: 3-BROMO-4-IODOTOLUENE;1-BROMO-2-IODO-5-METHYLBENZENE;2-Bromo-1-iodo-4-methylbenzene
• CAS NO: 71838-16-9
• Molecular Formula: C₇H₆BrI
• Molecular Weight: 296.93
• Product Categories: Halogen toluene;Bromine Compounds;Iodine Compounds
• Mol File: 71838-16-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: 265-267 °C
• Boiling Point: 133 °C
• Flash Point: 115.1 °C
• Appearance: /
• Density: 2,08 g/cm3
• Vapor Pressure: 0.014mmHg at 25°C
• Refractive Index: 1.636
• Storage Temp.: Refrigerated.
• CAS DataBase Reference: 3-BROMO-4-IODOTOLUENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-4-IODOTOLUENE(71838-16-9)
• EPA Substance Registry System: 3-BROMO-4-IODOTOLUENE(71838-16-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 71838-16-9(Hazardous Substances Data)

Usage

Uses

3-Bromo-4-iodotoluene, is an intermediate for the synthesis of more complex compounds. It is used for the copper-catalyzed synthesis of 2-Arylbenzoxazoles.

InChI:InChI=1/C7H6BrI/c1-5-2-3-7(9)6(8)4-5/h2-4H,1H3

Upstream product

• 67-66-3 chloroform 
• 591-17-3 meta-bromotoluene 
• 7553-56-2 iodine 
• 64-19-7 acetic acid 
• 103-89-9 4-Methylacetanilide 
• 106-49-0 p-toluidine 
• 583-68-6 2-bromo-p-toluidine 

Downstream Products

• 1085703-72-5 3,4-bis-diethylarsino-toluene 
• 71838-17-0 tetraethyl 4-methylbenzene-1,2-diphosphonate 
• 436850-39-4 2-bromo-4-methyl-1-(trimethylstannyl)benzene 
• 1039420-23-9 4-(2-bromo-4-methylphenyl)butanal 
• 863977-42-8 [(2-bromo-4-methyl-phenyl)-difluoro-methyl]-phosphonic acid diethyl ester 
• 1217102-41-4 C₁₂H₁₄N₂ 
• 18390-15-3 7-Methyl-1,2,3,4-tetrahydropyrido<1,2-a>benzimidazol 
• 1217102-36-7 4-(2,6-dimethylbenzimidazol-1-yl)benzonitrile 
• 873-74-5 4-Aminobenzonitrile 
• 1056894-82-6 2,6-dimethyl-1-phenyl-1H-benzo[d]imidazole 
• 24781-11-1 1-benzyl-6-methyl-2-phenyl-1H-benzo[d]imidazole 
• 1217102-29-8 1-isopropyl-6-methyl-2-phenyl-1H-benzimidazole 
• 1217102-34-5 2,6-dimethyl-1-o-tolyl-1H-benzimidazole 
• 959855-49-3 1-(4-methoxyphenyl)-2,6-dimethyl-1H-benzimidazole 

Relevant articles and documents

5, 10-dihydroindolo [3, 2-b] indole derivative and synthesis method and application thereof

The invention discloses a synthesis method of a 5, 10-dihydroindolo [3, 2-b] indole derivative, the method comprises the following steps: mixing a 2-((2-halogen phenyl) ethynyl)-N, N-dimethylaniline derivative (II), N, N-di-tert-butyl diazacycloketone (III), a palladium catalyst, a monophosphine ligand, alkali and a first organic solvent, and carrying out a diamidation reaction under the protection of inert gas to realize the synthesis of the 5, 10-dihydroindolo [3, 2-b] indole derivative(I). The method is easy to operate, mild in reaction condition and high in reaction yield, and the synthesized 5, 10-dihydroindolo [3, 2-b] indole derivative can be used for preparing an organic light-emitting device.

Regulating Transition-Metal Catalysis through Interference by Short RNAs

Herein we report the discovery of a AuI–DNA hybrid catalyst that is compatible with biological media and whose reactivity can be regulated by small complementary nucleic acid sequences. The development of this catalytic system was enabled by the discovery of a novel AuI-mediated base pair. We found that AuI binds DNA containing C-T mismatches. In the AuI–DNA catalyst's latent state, the AuI ion is sequestered by the mismatch such that it is coordinatively saturated, rendering it catalytically inactive. Upon addition of an RNA or DNA strand that is complementary to the latent catalyst's oligonucleotide backbone, catalytic activity is induced, leading to a sevenfold increase in the formation of a fluorescent product, forged through a AuI-catalyzed hydroamination reaction. Further development of this catalytic system will expand not only the chemical space available to synthetic biological systems but also allow for temporal and spatial control of transition-metal catalysis through gene transcription.

1-heterocyclyl-2-(heteroarylthio) benzene derivative and use method and application

The present invention discloses a 1-heterocyclyl-2-(heteroarylthio) benzene derivative and a use method and application, and in particular, relates to a novel 1-heterocyclyl-2-(heteroarylthio) benzene derivative and a pharmaceutical composition containing the novel 1-heterocyclyl-2-(heteroarylthio) benzene derivative, and the novel 1-heterocyclyl-2-(heteroarylthio) benzene derivative and the pharmaceutical composition can be used to inhibit 5-hydroxytryptamine reuptake. The present invention also relates to a preparation method of the novel 1-heterocyclyl-2-(heteroarylthio) benzene derivative and the pharmaceutical composition, and application of the novel 1-heterocyclyl-2-(heteroarylthio) benzene derivative and the pharmaceutical composition in the treatment of central nervous system functional disorders, particularly affective disorders.