5-BENZYLOXY-7-METHYLINDOLE

Base Information

• Chemical Name: 5-BENZYLOXY-7-METHYLINDOLE
• CAS No.: 4792-65-8
• Molecular Formula: C16H15NO
• Molecular Weight: 237.301
• Hs Code.: 2933990090
• Mol file: 4792-65-8.mol

Synonyms:5-BENZYLOXY-7-METHYLINDOLE;5-(Benzyloxy)-7-Methyl-1H-indole

Chemical Property of 5-BENZYLOXY-7-METHYLINDOLE

Chemical Property:

• PSA: 25.02000
• LogP: 4.05530
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-(Benzyloxy)-7-methyl-1H-indole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BENZYLOXY-7-METHYLINDOLE

There total 4 articles about 5-BENZYLOXY-7-METHYLINDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(benzyloxy)-1,3-dimethyl-2-nitrobenzene (68657-15-8) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 5-(benzyloxy)-7-methyl-1H-indole (4792-65-8)

Guidance literature:

5-(benzyloxy)-1,3-dimethyl-2-nitrobenzene; N,N-dimethyl-formamide dimethyl acetal; With pyrrolidine; In N,N-dimethyl-formamide; at 85 - 90 ℃; for 19h; Inert atmosphere;

With hydrogen; In ethyl acetate; at 20 - 25 ℃; under 760.051 Torr;

Reference yield:

3,5-dimethyl-4-nitrophenol (5344-97-8) → 5-(benzyloxy)-7-methyl-1H-indole (4792-65-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h

1.2: 1.5 h / 20 - 25 °C

2.1: pyrrolidine / N,N-dimethyl-formamide / 19 h / 85 - 90 °C / Inert atmosphere

2.2: Raney Nickel / 20 - 25 °C / 760.05 Torr

With pyrrolidine; caesium carbonate; In N,N-dimethyl-formamide;

Reference yield:

benzyl bromide (100-39-0) → 5-(benzyloxy)-7-methyl-1H-indole (4792-65-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h

1.2: 1.5 h / 20 - 25 °C

2.1: pyrrolidine / N,N-dimethyl-formamide / 19 h / 85 - 90 °C / Inert atmosphere

2.2: Raney Nickel / 20 - 25 °C / 760.05 Torr

With pyrrolidine; caesium carbonate; In N,N-dimethyl-formamide;

upstream raw materials:

5-(benzyloxy)-1,3-dimethyl-2-nitrobenzene

N,N-dimethyl-formamide dimethyl acetal

3,5-dimethyl-4-nitrophenol

benzyl bromide

Downstream raw materials:

tert-butyl 5-(benzyloxy)-7-methyl-1H-indole-1-carboxylate

Refernces