5344-97-8

Usage

InChI:InChI=1/C8H9NO3/c1-5-3-7(10)4-6(2)8(5)9(11)12/h3-4,10H,1-2H3

Upstream product

• 85450-73-3 2-Hydroxy-4,6-dimethyl-5-nitro-isophthalsaeure 
• 108-68-9 3,5-Dimethylphenol 
• 7664-93-9 sulfuric acid 
• 19628-76-3 3,5-dimethyl-4-nitrosophenol 
• 7722-84-1 dihydrogen peroxide 
• 68657-15-8 5-(benzyloxy)-1,3-dimethyl-2-nitrobenzene 
• 64-17-5 ethanol 
• 60-29-7 diethyl ether 
• 7697-37-2 nitric acid 
• 52177-27-2 5-ethoxy-1,3-dimethyl-2-nitrobenzene 
• 85450-68-6 2-Hydroxy-4,6-dimethyl-5-nitro-isophthalsaeurediethylester 

Downstream Products

• 61019-03-2 5-methoxy-1,3-dimethyl-2-nitrobenzene 
• 14033-85-3 4-Amino-3,5-dimethylphenol hydrochloride 
• 61019-01-0 2.4-dinitro-5-hydroxy-m-xylene 
• 857590-05-7 3,5-dimethyl-2,4-dinitro-anisole 
• 87405-27-4 2,6-dibromo-3,5-dimethyl-1,4-benzoquinone 
• 42288-43-7 (3,5-Dimethyl-4-nitro-phenoxy)-acetic acid 
• 52177-27-2 5-ethoxy-1,3-dimethyl-2-nitrobenzene 
• 68657-15-8 5-(benzyloxy)-1,3-dimethyl-2-nitrobenzene 
• 736074-26-3 2,6-dibromo-3,5-dimethyl-4-nitro-phenol 
• 13247-29-5 3,5-dimethyl-4-nitro-pyrocatechol 

Relevant academic research and scientific papers

BENZYLOXYANILIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS

The present invention relates to benzyloxyanilide derivatives having the following structural formula: I The compounds of the present invention are useful for the treatment and prevention of diseases and disorders which are affected by activation or modul

Fast deprotection of phenoxy benzyl ethers in transfer hydrogenation assisted by microwave

Phenoxy benzyl ethers are easily and quickly deprotected in the presence of ammonium formate and microencapsulated Pd(0)EnCat with the assistance of microwave irradiation. This procedure can be applied in the presence of other functional groups as well. The described protocol is particularly convenient for the preparation in a parallel and automatic fashion of libraries of compounds possessing a phenol type moiety.

Nitration of substituted phenols by different efficient heterogeneous systems

Nitration of substituted phenols were carried out by the mixture of sodium nitrite and wet SiO2 (50% w/w) in the presence of four different efficient heterogeneous systems: 1) oxalic acid dihydrate (I), 2) sodium hydrogen sulphate (II), 3) aluminum hydrogen sulphate (III) and 4) silica sulphuric acid (IV) in CH2Cl2 at room temperature and high yields. Optimum conditions for theses systems and the regioselectivities of the reactions are reported.

HIV REPLICATION INHIBITING PURINE DERIVATIVES

The present invention relates to the use of a compound of formula (I) for the manufacture of a medicament for the prevention or the treatment of HIV infection wherein the compound of formula (I) is a compound of formula (I) a N-oxide, a pharmaceutically a

Local anesthetic compounds and uses

Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a ligand binding site in a voltage-gated Na+channel to modulate the biological processes/functions thereof.

LOCAL ANESTHETIC COMPOUNDS AND USES

Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a ligand binding site in a voltage-gated Na + channel to modulate the biological processes/functions thereof.

Imidazoquinoxaline protein tyrosine kinase inhibitors

Novel imidazoquinoxalines and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic disorders.

Direct Observation of the Cyclopropene-Vinylcarbene Rearrangement. Matrix Isolation of Bicyclohexa-3,5-dien-2-ones

4-Oxocyclohexa-2,5-dienylidenes 4b-g have been generated in argon matrices at 10 K by visible-light irradiation of the corresponding quinone diazides 5.Carbenes 4 have been characterized by IR and UV-vis spectroscopy and by their characteristic thermal reaction with molecular oxygen.On irradiation into the longest-wavelength absorption (420-700 nm), carbenes 4c-g rearrange to give the highly strained bicyclohexa-3,5-dien-2-ones 3c-g while 4b is photostable under the same conditions.The photochemical 4 -> 3 rearrangement is completely reversible: infrared irradiation or visible light irradiation (λ > 470 nm) of the cyclopropenes 3 lead back to triplet carbenes 4 quantitatively.In addition, several of the 1,3-bridged cyclopropenes 3 undergo a thermal rearrangement to give carbenes 4.This indicates that the highly strained cyclopropenes 3 are thermodynamically less stable than the corresponding carbenes 4 and kinetically only stabilized by a shallow energy barrier.Even under the conditions of matrix isolation at cryogenic temperatures, cyclopropenes 3 are metastable compounds.

FORMATION OF DIENONES ON THE REACTION OF CRESOLS, XYLENOLS, AND 2-NAPHTHOL WITH NITROGEN DIOXIDE: OBSERVATION OF KETO TAUTOMERS OF NITROPHENOLS

Reaction of o- and p-cresol, the xylenols, and 2-naphthol with nitrogen dioxide gives nitrocyclohexadienones and nitrophenols.Secondary nitrodienones, the keto tautomers of the nitrophenols, have been observed in several cases and are intermediates in the formation of the nitrophenols.

NITRATION OF PHENOLS WITH NITRATES IN A TWO-PHASE SYSTEM

Phenols are easily nitrated at room temperature, with good selectivity, by dilute nitric acid or metallic nitrates, in an acidic two-phase system, even without phase transfert catalyst.The results, in these experimental conditions, suggest an electron transfer mechanism for this reaction.