1H-Indole-4-carboxaMide,6-broMo-N-[(1,2-dihydro-4,6-diMethyl-2-oxo-3-pyridinyl)Methyl]-3-Methyl-1-(1-Methylpropyl)-

Base Information

Chemical Name:1H-Indole-4-carboxaMide,6-broMo-N-[(1,2-dihydro-4,6-diMethyl-2-oxo-3-pyridinyl)Methyl]-3-Methyl-1-(1-Methylpropyl)-
CAS No.:1346574-53-5
Molecular Formula:C22H26BrN3O2
Molecular Weight:444.371
Hs Code.:
Mol file:1346574-53-5.mol

Synonyms:1H-Indole-4-carboxaMide,6-broMo-N-[(1,2-dihydro-4,6-diMethyl-2-oxo-3-pyridinyl)Methyl]-3-Methyl-1-(1-Methylpropyl)-;6-bromo-1-sec-butyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-1H-indole-4-carboxamide

Suppliers and Price of 1H-Indole-4-carboxaMide,6-broMo-N-[(1,2-dihydro-4,6-diMethyl-2-oxo-3-pyridinyl)Methyl]-3-Methyl-1-(1-Methylpropyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Indole-4-carboxaMide,6-broMo-N-[(1,2-dihydro-4,6-diMethyl-2-oxo-3-pyridinyl)Methyl]-3-Methyl-1-(1-Methylpropyl)-

Chemical Property:

PSA：66.89000
LogP:5.30920

Purity/Quality:: NLT 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Indole-4-carboxaMide,6-broMo-N-[(1,2-dihydro-4,6-diMethyl-2-oxo-3-pyridinyl)Methyl]-3-Methyl-1-(1-Methylpropyl)-

There total 7 articles about 1H-Indole-4-carboxaMide,6-broMo-N-[(1,2-dihydro-4,6-diMethyl-2-oxo-3-pyridinyl)Methyl]-3-Methyl-1-(1-Methylpropyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 771579-27-2
3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one

: 1346575-54-9
6-bromo-1-(sec-butyl)-3-methyl-1H-indole-4-carboxylic acid

: 1346574-53-5
6-bromo-N-[(4,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-(1-methylpropyl)-1H-indole-4-carboxamide

Guidance literature:: With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dimethyl sulfoxide; at 20 ℃; for 32h; Inert atmosphere; Sealed tube;

Reference yield:

: 107650-22-6
methyl 6-bromo-1-isopropyl-3-methyl-1H-indole-4-carboxylate

: 1346574-53-5
6-bromo-N-[(4,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-(1-methylpropyl)-1H-indole-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere

1.2: 16 h / 0 - 20 °C / Inert atmosphere

2.1: trichlorophosphate / 0.5 h / 0 °C / Inert atmosphere

2.2: 2.5 h / 0 - 20 °C / Inert atmosphere

3.1: sulfolane; toluene-4-sulfonic acid; toluene-4-sulfonic acid hydrazide / N,N-dimethyl-formamide / 1 h / 100 °C / Inert atmosphere

3.2: 2 h / 100 °C / Inert atmosphere

4.1: sodium hydroxide / methanol; tetrahydrofuran; water / 65 h / 20 °C / Inert atmosphere

5.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / dimethyl sulfoxide / 32 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; sulfolane; 1-hydroxy-7-aza-benzotriazole; sodium hydride; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; toluene-4-sulfonic acid hydrazide; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 107650-20-4
5-bromo-2-methyl-3-nitro-benzoic acid

: 1346574-53-5
6-bromo-N-[(4,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-(1-methylpropyl)-1H-indole-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: N,N-dimethyl-formamide / 18 h / 115 °C / Inert atmosphere

1.2: 4 h / 50 - 90 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere

2.2: 16 h / 0 - 20 °C / Inert atmosphere

3.1: trichlorophosphate / 0.5 h / 0 °C / Inert atmosphere

3.2: 2.5 h / 0 - 20 °C / Inert atmosphere

4.1: sulfolane; toluene-4-sulfonic acid; toluene-4-sulfonic acid hydrazide / N,N-dimethyl-formamide / 1 h / 100 °C / Inert atmosphere

4.2: 2 h / 100 °C / Inert atmosphere

5.1: sodium hydroxide / methanol; tetrahydrofuran; water / 65 h / 20 °C / Inert atmosphere

6.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / dimethyl sulfoxide / 32 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; sulfolane; 1-hydroxy-7-aza-benzotriazole; sodium hydride; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; toluene-4-sulfonic acid hydrazide; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;