(1R,2S)-ethyl 1-((2S,4R)-4-hydroxypyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylate hydrochloride

Base Information

Chemical Name:(1R,2S)-ethyl 1-((2S,4R)-4-hydroxypyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylate hydrochloride
CAS No.:924305-02-2
Molecular Formula:
Molecular Weight:304.77
Hs Code.:

Synonyms:(1R,2S)-ethyl 1-((2S,4R)-4-hydroxypyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylate hydrochloride

Suppliers and Price of (1R,2S)-ethyl 1-((2S,4R)-4-hydroxypyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylate hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2S)-ethyl 1-((2S,4R)-4-hydroxypyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylate hydrochloride

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of (1R,2S)-ethyl 1-((2S,4R)-4-hydroxypyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylate hydrochloride

There total 11 articles about (1R,2S)-ethyl 1-((2S,4R)-4-hydroxypyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 862119-82-2
(2S,4R)-tert-butyl 2-((1R,2S)-1-(ethoxycarbonyl)-2-vinylcyclopropylcarbamoyl)-4-hydroxypyrrolidine-1-carboxylate

: 924305-02-2
(1R,2S)-ethyl 1-((2S,4R)-4-hydroxypyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylate hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane;

Reference yield:

: 1393095-18-5
(E)-ethyl 1-(benzylideneamino)-2-vinylcyclopropanecarboxylate

: 924305-02-2
(1R,2S)-ethyl 1-((2S,4R)-4-hydroxypyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; water / tert-butyl methyl ether / 2 h / 20 °C

1.2: 0 °C / pH 14

2.1: hydrogenchloride / 1,4-dioxane

3.1: 4-methyl-morpholine; HATU / dichloromethane / 18 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 3 h

With 4-methyl-morpholine; hydrogenchloride; water; HATU; In 1,4-dioxane; dichloromethane; tert-butyl methyl ether;

Reference yield:

: 787548-29-2,213316-32-6,259221-73-3
(1R,2S)/(1S,2R) 1-amino-2-vinylcyclopropane carboxylic acid ethyl ester

: 924305-02-2
(1R,2S)-ethyl 1-((2S,4R)-4-hydroxypyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane

2: 4-methyl-morpholine; HATU / dichloromethane / 18 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 3 h

With 4-methyl-morpholine; hydrogenchloride; HATU; In 1,4-dioxane; dichloromethane;