Ethyl 3-EthylMorpholine-3-carboxylate

Base Information

• Chemical Name: Ethyl 3-EthylMorpholine-3-carboxylate
• CAS No.: 1305287-88-0
• Molecular Formula: C9H17NO3
• Molecular Weight: 187.23618
• Mol file: 1305287-88-0.mol

Synonyms:Ethyl 3-EthylMorpholine-3-carboxylate;3-ethyl-3-morpholinecarboxylic acid ethyl ester

Chemical Property of Ethyl 3-EthylMorpholine-3-carboxylate

Chemical Property:

• Boiling Point: 245.4±30.0 °C(Predicted)
• PKA: 7.15±0.40(Predicted)
• PSA: 47.56000
• Density: 1.019±0.06 g/cm3(Predicted)
• LogP: 0.64690

Purity/Quality:

97% ^*data from raw suppliers

Ethyl3-Ethylmorpholine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 3-EthylMorpholine-3-carboxylate

There total 3 articles about Ethyl 3-EthylMorpholine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

ethyl 2-amino-2-[(2-chloroethoxy)methyl]butanoate (1305287-91-5) → ethyl 3-ethylmorpholine-3-carboxylate (1305287-88-0)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; sodium iodide; In acetonitrile; at 20 - 52 ℃; Inert atmosphere;

DOI:10.1016/j.tetlet.2011.03.003

Reference yield:

ethyl 2-[(4-chlorobenzylidene)amino]butanoate (126385-72-6) → ethyl 3-ethylmorpholine-3-carboxylate (1305287-88-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / -70 °C / Inert atmosphere

1.2: -70 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / tetrahydrofuran; water / 0.33 h / 10 °C

3.1: tetra-(n-butyl)ammonium iodide; potassium carbonate; sodium iodide / acetonitrile / 20 - 52 °C / Inert atmosphere

With hydrogenchloride; potassium tert-butylate; tetra-(n-butyl)ammonium iodide; potassium carbonate; sodium iodide; In tetrahydrofuran; water; acetonitrile;

DOI:10.1016/j.tetlet.2011.03.003

Reference yield:

ethyl 2-aminobutyrate hydrochloride (55410-21-4) → ethyl 3-ethylmorpholine-3-carboxylate (1305287-88-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: magnesium sulfate; triethylamine / dichloromethane / 96 h / 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / -70 °C / Inert atmosphere

2.2: -70 - 20 °C / Inert atmosphere

3.1: hydrogenchloride / tetrahydrofuran; water / 0.33 h / 10 °C

4.1: tetra-(n-butyl)ammonium iodide; potassium carbonate; sodium iodide / acetonitrile / 20 - 52 °C / Inert atmosphere

With hydrogenchloride; potassium tert-butylate; tetra-(n-butyl)ammonium iodide; magnesium sulfate; potassium carbonate; triethylamine; sodium iodide; In tetrahydrofuran; dichloromethane; water; acetonitrile;

DOI:10.1016/j.tetlet.2011.03.003

upstream raw materials:

ethyl 2-amino-2-[(2-chloroethoxy)methyl]butanoate

ethyl 2-[(4-chlorobenzylidene)amino]butanoate

ethyl 2-aminobutyrate hydrochloride