4'-METHYL-2(P-TOLYL SULFONYL)ACETOPHENONE

Base Information

• Chemical Name: 4'-METHYL-2(P-TOLYL SULFONYL)ACETOPHENONE
• CAS No.: 61820-95-9
• Molecular Formula: C16H16O3S
• Molecular Weight: 288.367
• Hs Code.: 2914399090
• Mol file: 61820-95-9.mol

Synonyms:4-Methylphenacyl 4'-tolyl sulfone;

Chemical Property of 4'-METHYL-2(P-TOLYL SULFONYL)ACETOPHENONE

Chemical Property:

• Vapor Pressure: 6.88E-10mmHg at 25°C
• Melting Point: 101-103oC
• Boiling Point: 493.7°Cat760mmHg
• Flash Point: 313.6°C
• PSA: 59.59000
• Density: 1.203g/cm³
• LogP: 4.04080

Purity/Quality:

97% ^*data from raw suppliers

4'-METHYL-2-(P-TOLYLSULFONYL)ACETOPHENONE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4'-METHYL-2(P-TOLYL SULFONYL)ACETOPHENONE

There total 57 articles about 4'-METHYL-2(P-TOLYL SULFONYL)ACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

sodium 4-methylbenzenesulfinate (824-79-3) + 4-(bromoacetyl)toluene (619-41-0) → 2-(toluene-4-sulfonyl)-1-p-tolylethanone (61820-95-9)

Guidance literature:

In 1,4-dioxane; water; Reflux;

DOI:10.1055/s-0036-1589479

Reference yield: 95.7%

2-bromo-1-(p-tolyl)ethanol (60655-81-4) + toluene-4-sulfonamide (70-55-3) → 2-(toluene-4-sulfonyl)-1-p-tolylethanone (61820-95-9)

Guidance literature:

With cerium(III) chloride; [bis(acetoxy)iodo]benzene; 1-(1-ferroceneamidoethyl)-3-isopropylimidazole; copper(II) bis(trifluoromethanesulfonate); 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide; at 55 ℃; for 7h;

Reference yield: 95.0%

4‐methylacetophenone oxime acetate (96475-75-1) + sodium 4-methylbenzenesulfinate (824-79-3) → 2-(toluene-4-sulfonyl)-1-p-tolylethanone (61820-95-9)

Guidance literature:

4‐methylacetophenone oxime acetate; sodium 4-methylbenzenesulfinate; With copper diacetate; In dimethyl sulfoxide; at 100 ℃; for 6h; Schlenk technique; Inert atmosphere;

With silica gel; In dichloromethane; at 20 ℃;

DOI:10.1002/anie.201311217

upstream raw materials:

1-(p-tolyl)-2-(p-tolylthio)ethan-1-one

1-p-methylphenyl-1-trimethylsiloxyethene

p-toluenesulfonyl chloride

4-n-methylphenylacetylene

Downstream raw materials:

(E)-1-Phenyl-3-pyridin-4-yl-2-(toluene-4-sulfonyl)-propenone

(E)-3-Pyridin-4-yl-2-(toluene-4-sulfonyl)-1-p-tolyl-propenone

(E)-3-(4-Chloro-phenyl)-2-(toluene-4-sulfonyl)-1-p-tolyl-propenone

1-Phenyl-2-(toluene-4-sulfonyl)-3-p-tolylpropenone