5-(2,5-DICHLORO-PHENYL)-FURAN-2-CARBONYL CHLORIDE

Base Information

• Chemical Name: 5-(2,5-DICHLORO-PHENYL)-FURAN-2-CARBONYL CHLORIDE
• CAS No.: 380906-80-9
• Molecular Formula: C11H5Cl3O2
• Molecular Weight: 275.52
• Hs Code.: 2932190090
• Mol file: 380906-80-9.mol

Synonyms:AKOS BB-8322;5-(2,5-DICHLORO-PHENYL)-FURAN-2-CARBONYL CHLORIDE;ASISCHEM T31185;ART-CHEM-BB B025334;LABOTEST-BB LT00569156

Chemical Property of 5-(2,5-DICHLORO-PHENYL)-FURAN-2-CARBONYL CHLORIDE

Chemical Property:

• Melting Point: 129-130 °C(Solv: benzene (71-43-2))
• Boiling Point: 175-180 °C(Press: 2 Torr)
• PSA: 30.21000
• Density: 1.466±0.06 g/cm3(Predicted)
• LogP: 4.63240
• Sensitive.: Moisture Sensitive

Purity/Quality:

99% ^*data from raw suppliers

5-(2,5-DICHLORO-PHENYL)-FURAN-2-CARBONYL CHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2,5-DICHLORO-PHENYL)-FURAN-2-CARBONYL CHLORIDE

There total 4 articles about 5-(2,5-DICHLORO-PHENYL)-FURAN-2-CARBONYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

5-(2,5-dichlorophenyl)furan-2-carboxylic acid (186830-98-8) → C11H5Cl3O2 (380906-80-9)

Guidance literature:

With thionyl chloride; In benzene; Reflux;

DOI:10.1134/S1070428009040125

Reference yield:

methyl 5-bromo-2-furoate (2527-99-3) → C11H5Cl3O2 (380906-80-9)

Guidance literature:

Multi-step reaction with 3 steps

1: Na₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 100 °C

2: aq. LiOH / tetrahydrofuran

3: (COCl)2 / tetrahydrofuran

With lithium hydroxide; oxalyl dichloride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; 1: Suzuki coupling;

DOI:10.1016/j.bmcl.2007.04.022

Reference yield:

2,5-dichlorobenzeneboronic acid (135145-90-3) → C11H5Cl3O2 (380906-80-9)

Guidance literature:

Multi-step reaction with 3 steps

1: Na₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 100 °C

2: aq. LiOH / tetrahydrofuran

3: (COCl)2 / tetrahydrofuran

With lithium hydroxide; oxalyl dichloride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; 1: Suzuki coupling;

DOI:10.1016/j.bmcl.2007.04.022

upstream raw materials:

5-(2,5-dichlorophenyl)furan-2-carboxylic acid

5-(2,5-dichlorophenyl)furan-2-carboxylic acid methyl ester

methyl 5-bromo-2-furoate

2,5-dichlorobenzeneboronic acid