3α-Acetoxy-7,12-dioxo-5β-cholan-24-oic acid methyl ester

Base Information

• Chemical Name: 3α-Acetoxy-7,12-dioxo-5β-cholan-24-oic acid methyl ester
• CAS No.: 7753-73-3
• Molecular Formula: C27H40O6
• Molecular Weight: 460.611
• Mol file: 7753-73-3.mol

Synonyms:3α-Acetoxy-7,12-dioxo-5β-cholan-24-oic acid methyl ester;3α-Acetyloxy-7,12-dioxo-5β-cholan-24-oic acid methyl ester

Chemical Property of 3α-Acetoxy-7,12-dioxo-5β-cholan-24-oic acid methyl ester

Chemical Property:

• PSA: 86.74000
• LogP: 4.52430

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3α-Acetoxy-7,12-dioxo-5β-cholan-24-oic acid methyl ester

There total 9 articles about 3α-Acetoxy-7,12-dioxo-5β-cholan-24-oic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl cholate 3-acetate (7443-91-6) → Methyl 3α-acetyloxy-7,12-dioxo-5β-cholan-24-oate (7753-73-3)

Guidance literature:

With potassium chromate; acetic acid; for 48h; Ambient temperature;

DOI:10.1055/s-1999-3114

Reference yield:

cholic acid (81-25-4) → Methyl 3α-acetyloxy-7,12-dioxo-5β-cholan-24-oate (7753-73-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / p-TsOH*H₂O / 48 h / Heating

2: 98 percent / aq. calcium hypochlorite; acetic acid; KBr / 20 °C

With calcium hypochlorite; toluene-4-sulfonic acid; acetic acid; potassium bromide;

DOI:10.1039/b412298d

Reference yield:

cholic acid (81-25-4) → Methyl 3α-acetyloxy-7,12-dioxo-5β-cholan-24-oate (7753-73-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / p-TsOH / 23 h / Heating

2: 98 percent / K₂CrO₄, AcOH / 48 h / Ambient temperature

With potassium chromate; toluene-4-sulfonic acid; acetic acid;

DOI:10.1055/s-1999-3114

upstream raw materials:

methyl cholate 3-acetate

6α-bromo-3α-acetoxy-7,12-dioxo-5β-cholanoic acid-(24)-methyl ester

N,N-dimethyl-aniline

diazomethane

Downstream raw materials:

methyl 3α-hydroxy-7,12-dioxo-5β-cholan-24-oate

Lithocholic acid