7443-91-6Relevant articles and documents
New cyclic dimers of cholic acid
Lotowski, Zenon,Guzmanski, Dariusz
, p. 153 - 158 (2005)
Two new cyclic dimers of cholic acid were obtained in the reaction of 3-O-acetyl methyl cholate with oxalyl chloride. The oxalates bound the cholate subunits "side-to-side" as a result of acylation of 7α and 12α OH groups in the substrate. The selective deprotection of hydroxy groups at C-3 and C-24 proved to be rather difficult and led to various products depending on the reaction conditions. Springer-Verlag 2005.
Mimicking Enzymes: Asymmetric Induction inside a Carbamate-Based Steroidal Cleft
Concellón, Carmen,Martín, Judith,Gallegos, Miguel,Fanjul-Mosteirín, Noé,Costales, Aurora,Pendás, ángel Martín,Del Amo, Vicente
supporting information, p. 3994 - 3997 (2019/06/17)
Cholic acid has been elaborated into a carbamate-based tripodal architecture, which is able to promote an asymmetric organic transformation inside its chiral cavity. The nature of this steroidal catalyst has been disclosed by quantum-chemical calculations. It comprises the preorganization and confinement of the reagents within the cavity of the steroid to form a supramolecular complex held together by means of cooperative H-bond contacts. This operational mode resembles that of some enzymes.
Differentially-protected steroidal triamines; scaffolds with potential for medicinal, supramolecular, and combinatorial chemistry
Amo, Vicente Del,Siracusa, Laura,Markidis, Theodoros,Baragana, Beatriz,Bhattarai, Khadga M.,Galobardes, Marta,Naredo, Gregorio,Perez-Payan, M. Nieves,Davis, Anthony P.
, p. 3320 - 3328 (2007/10/03)
Cholic acid 2a has been converted into two new orthogonally-protected triamino scaffolds, 13 and 14. The synthesis proceeds via the bis-Boc-NH-substituted azide 10, for which an improved preparation is described. After removal of the Boc groups, the two a
