alpha,alpha-Dimethyl-1-(phenylmethyl)-4-piperidinemethanol

Base Information

• Chemical Name: alpha,alpha-Dimethyl-1-(phenylmethyl)-4-piperidinemethanol
• CAS No.: 299428-04-9
• Molecular Formula: C15H23NO
• Molecular Weight: 233.354
• Mol file: 299428-04-9.mol

Synonyms:2-(1-Benzylpiperidin-4-yl)propan-2-ol;alpha,alpha-Dimethyl-1-(phenylmethyl)-4-piperidinemethanol;2-(1-Benzylpiperidin-4-yl)-2-propanol

Chemical Property of alpha,alpha-Dimethyl-1-(phenylmethyl)-4-piperidinemethanol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 331ºC
• Flash Point: 139℃
• PSA: 23.47000
• Density: 1.046
• LogP: 2.60740
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-(1-Benzylpiperidin-4-yl)-2-propanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of alpha,alpha-Dimethyl-1-(phenylmethyl)-4-piperidinemethanol

There total 5 articles about alpha,alpha-Dimethyl-1-(phenylmethyl)-4-piperidinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1-benzylpiperidine-4-carboxylic acid methyl ester (10315-06-7) + methylmagnesium bromide (75-16-1) → N-benzyl-4-(2-hydroxy-2-propyl)piperidine (299428-04-9)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.3998/ark.5550190.0011.a12

Reference yield:

methyllithium (917-54-4) + N-benzyl isonipecotic acid ethyl ester (24228-40-8) → N-benzyl-4-(2-hydroxy-2-propyl)piperidine (299428-04-9)

Guidance literature:

methyllithium; N-benzyl isonipecotic acid ethyl ester; In tetrahydrofuran; at -78 - 23 ℃;

With water; at 23 ℃;

Reference yield:

N-benzyl isonipecotic acid ethyl ester (24228-40-8) → N-benzyl-4-(2-hydroxy-2-propyl)piperidine (299428-04-9)

Guidance literature:

With methyllithium; In tetrahydrofuran; at -78 - 20 ℃;

upstream raw materials:

methylmagnesium bromide

N-benzyl isonipecotic acid ethyl ester

methyllithium

1-benzylpiperidine-4-carboxylic acid methyl ester

Downstream raw materials:

2-(piperidin-4-yl)propan-2-ol

Refernces

• 1、 Moosa, Basem A.,Ali, Shaikh A.. "Regioselective transformation of 6/5-fused bicyclic isoxazolidines to second-generation cyclic aldonitrones". experimental part. p. 132 - 148. Retrieved 2010/12/25.
• 2、 -. "PHOSPHODIESTERASE 10 INHIBITORS". Page/Page column 13. . Retrieved 2009/04/24.